Evidence map›Paper›PMID 32928882›Full record

ArticleeNeuro

Registered Report: Transcriptional Analysis of Savings Memory Suggests Forgetting is Due to Retrieval Failure.

Tania Rosiles, Melissa Nguyen, Monica Duron, Annette Garcia, George Garcia, Hannah Gordon, Lorena Juarez, Irina E Calin-Jageman, Robert J Calin-Jageman

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tania RosilesNeuroscience Program, Dominican University, River Forest, Illinois 60305.
Melissa NguyenNeuroscience Program, Dominican University, River Forest, Illinois 60305.
Monica DuronNeuroscience Program, Dominican University, River Forest, Illinois 60305.
Annette GarciaNeuroscience Program, Dominican University, River Forest, Illinois 60305.
George GarciaNeuroscience Program, Dominican University, River Forest, Illinois 60305.
Hannah GordonNeuroscience Program, Dominican University, River Forest, Illinois 60305.
Lorena JuarezNeuroscience Program, Dominican University, River Forest, Illinois 60305.
Irina E Calin-JagemanNeuroscience Program, Dominican University, River Forest, Illinois 60305.ORCID 0000-0002-2529-4223
Robert J Calin-JagemanNeuroscience Program, Dominican University, River Forest, Illinois 60305 rcalinjageman@dom.edu.ORCID 0000-0002-9837-6529
Dominican University · US

Funding

Transcriptional mechanisms of maintaining and forgetting long-term memoryR15MH107892 · NIMH · DOMINICAN UNIVERSITY · PI CALIN-JAGEMAN, IRINA ELENA, CALIN-JAGEMAN, ROBERT JOSEPH · 2015 to 2025
$1.3M
NIMH NIH HHS R15 MH107892
6 · The paper itself

Abstract

There is fundamental debate about the nature of forgetting: some have argued that it represents the decay of the memory trace, others that the memory trace persists but becomes inaccessible because of retrieval failure. These different accounts of forgetting lead to different predictions about savings memory, the rapid re-learning of seemingly forgotten information. If forgetting is because of decay, then savings requires re-encoding and should thus involve the same mechanisms as initial learning. If forgetting is because of retrieval failure, then savings should be mechanistically distinct from encoding. In this registered report, we conducted a preregistered and rigorous test between these accounts of forgetting. Specifically, we used microarray to characterize the transcriptional correlates of a new memory (1 d after training), a forgotten memory (8 d after training), and a savings memory (8 d after training but with a reminder on day 7 to evoke a long-term savings memory) for sensitization in

Indexed as

MemoryMemory, Long-TermAnimalsAplysiaLearningMicroarray Analysislatent memorylong-term memorysensitizationtranscription

Identifiers

PMID32928882
PMCPMC7665899
OpenAlexW3086982507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.