Evidence map›Paper›PMID 32928877›Full record

Observational studyCancer prevention research (Philadelphia, Pa.)2021

Genome-wide Association Analysis of Proinflammatory Cytokines and Gene-lifestyle Interaction for Invasive Breast Cancer Risk: The WHI dbGaP Study.

Su Yon Jung, Peter A Scott, Jeanette C Papp, Eric M Sobel, Matteo Pellegrini, Herbert Yu, Sihao Han, Zuo-Feng Zhang

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer prevention research (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Omics-Based Investigations of Breast Cancer.Molecules (Basel, Switzerland) · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Su Yon JungTranslational Sciences Section, Jonsson Comprehensive Cancer Center, School of Nursing, University of California, Los Angeles, Los Angeles, California. sjung@sonnet.ucla.edu.
Peter A ScottDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0002-3402-0670
Jeanette C PappDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Eric M SobelDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0002-1718-0031
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology, Life Sciences Division, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-9355-9564
Herbert YuCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.ORCID 0000-0003-3950-4815
Sihao HanDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California.
Zuo-Feng ZhangDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0002-4669-3995
University of California, Los Angeles · USCancer Center of Hawaii · US

Funding

Insulin-Resistance Genetic and Epigenetic Variants and Their Interactions with Lifestyle Factors in Postmenopausal Breast CancerK01NR017852 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JUNG, SU YON · 2019 to 2021
$289k
NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNINR NIH HHS K01 NR017852WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

Immune-related etiologic pathways to influence invasive breast cancer risk may interact with lifestyle factors, but the interrelated molecular genetic pathways are incompletely characterized. We used data from the Women's Health Initiative Database for Genotypes and Phenotypes Study including 16,088 postmenopausal women, a population highly susceptible to inflammation, obesity, and increased risk for breast cancer. With 21,784,812 common autosomal single-nucleotide polymorphisms (SNP), we conducted a genome-wide association (GWA) gene-environment interaction (G × E) analysis in six independent GWA Studies for proinflammatory cytokines [IL6 and C-reactive protein (CRP)] and their gene-lifestyle interactions. Subsequently, we tested for the association of the GWA SNPs with breast cancer risk. In women overall and stratified by obesity status (body mass index, waist circumference, and waist-to-hip ratio) and obesity-related lifestyle factors (exercise and high-fat diet), 88 GWA SNPs in 10 loci were associated with proinflammatory cytokines: 3 associated with IL6 (1 index SNP in

Indexed as

Gene-Environment InteractionAgedBiomarkers, TumorBreast NeoplasmsCytokinesFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLife StyleMiddle AgedObesityPolymorphism, Single NucleotidePostmenopauseRisk FactorsBiomarkers, TumorCytokines

Identifiers

PMID32928877
PMCPMC7956151
OpenAlexW3085870051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.