Evidence map›Paper›PMID 32928869›Full record

SynthesisBMJ open gastroenterology2020

Wide-area transepithelial sampling in adjunct to forceps biopsy increases the absolute detection rates of Barrett's oesophagus and oesophageal dysplasia: a meta-analysis and systematic review.

Vishnu Charan Suresh Kumar, Prateek Harne, Venkata Suresh Patthipati, Abinash Subedi, Umair Masood, Anuj Sharma, Faith Goyal, Nancy Aggarwal, Bishnu Sapkota

Open access · goldAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Barrett's Esophagus: An Updated Review.Diagnostics (Basel, Switzerland) · 2023
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Vishnu Charan Suresh KumarDepartment of Internal Medicine, SUNY Upstate Medical University, Syracuse, New York, USA drvishnucharan@gmail.com.ORCID 0000-0002-9472-2869
Prateek HarneDepartment of Internal Medicine, SUNY Upstate Medical University, Syracuse, New York, USA.
Venkata Suresh PatthipatiDepartment of Internal Medicine, Trumbull Regional Medical Center, Warren, Ohio, USA.
Abinash SubediDepartment of Internal Medicine, SUNY Upstate Medical University, Syracuse, New York, USA.
Umair MasoodDivision of Gastroenterology, SUNY Upstate Medical University, Syracuse, New York, USA.
Anuj SharmaDivision of Gastroenterology, SUNY Upstate Medical University, Syracuse, New York, USA.
Faith GoyalDepartment of Electronics and Communication Engineering, Maharaja Agrasen Institute of Technology, Delhi, India.
Nancy AggarwalDepartment of Physics, Northwestern University, Evanston, Illinois, USA.
Bishnu SapkotaDivision of Gastroenterology, SUNY Upstate Medical University, Syracuse, New York, USA.
SUNY Upstate Medical University · USMaharaja Engineering College · INNorthwestern University · USRegional Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWide-area transepithelial sampling (WATS) is a new technique that uses an abrasive brush to obtain samples from a larger surface area of the oesophagus. Studies have shown promising results that WATS in adjunct to forceps biopsy (FB) increases the detection rate of Barrett's oesophagus (BE) as well as oesophageal dysplasia (ED). We conducted a systematic review and meta-analysis to compare the detection rates of BE and ED between FB and WATS in adjunct to FB.

methodsA Literature search was done using electronic databases, including PubMed, Embase, Scopus, Cochrane and CINAHL from inception to 26 April 2020. A meta-analysis comparing detection rates of WATS in adjunct to FB versus FB using the random-effects model was done using RevMan V.5.3.

resultsPooled data from 20 392 endoscopies across 11 studies showed an absolute increase in detection of 16% (95% CI 0.10% to 0.22%, p<0.00001). A relative increase of 1.62 was seen in detection rates of BE (95% CI 1.28 to 2.05, p<0.0001) when WATS was used with FB with the number needed to test (NNT) of 6.1 patients. For ED, a 2% absolute increase (95% CI 0.01 to 0.03, p=0.001) in additional diagnostic yield from WATS. A relative increase of 2.05 was seen in the detection rate of ED (95% CI 1.42 to 2.98, p=0.0001) yielding an NNT of 50 patients.

conclusionOur study shows that WATS, as an adjunct to FB, improves both the absolute detection rate and relative detection rate of both BE and ED as compared to FB alone.

Indexed as

AgedBarrett EsophagusBiopsyData ManagementDiagnostic Techniques, Digestive SystemEsophageal NeoplasmsEsophagusFemaleHumansMaleMass ScreeningMiddle AgedOutcome Assessment, Health CareSpecimen HandlingSurgical InstrumentsUnited StatesBarrett's metaplasiaBarrett's oesophagusEndoscopic proceduresOesophageal lesions

Identifiers

PMID32928869
PMCPMC7488841
OpenAlexW3086647108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.