ArticleBMJ open2020
Factors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort study.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Dengue virus infection and Guillain-Barré syndrome: a systematic review of clinical characteristics, outcomes, and predictors of severity.BMC infectious diseases · 2025Pooled it
- Routine blood parameters of dengue infected children and adults. A meta-analysis.Pathogens and global health · 2023Pooled it
- Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis.Parasites & vectors · 2022Pooled it
- Coagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2021Pooled it
- The protective role of metformin against severe dengue disease in patients with type 2 diabetes mellitus: a preliminary report in Mexico.World journal of emergency medicine · 2025Article
- Inter-host diversity associated with age, sex, and menstrual cycle modulates clinical manifestations in DENV-2 patients.iScience · 2025Article
- Aberrant systemic acute-phase complement responses in conjunction with soluble CR1 attribute to varying grades of dengue disease severity.Frontiers in immunology · 2025Article
- Unmasking Hepatitis A: A Case Study of Atypical Presentation in a Returning Traveler From Egypt.Case reports in hepatology · 2025Article
- Dengue Fever in an Adult Presenting as Immune Thrombocytopenic Purpura (ITP): A Case Report.Cureus · 2024Article
- Article
- Retrospective study on the dengue fever outbreak in Puntland State, Somalia.BMC infectious diseases · 2024Article
- Immuno-Haematologic Aspects of Dengue Infection: Biologic Insights and Clinical Implications.Viruses · 2024Review
- Linezolid-Associated Thrombocytopenia: Assessment of Risk Factors in Patients without Hemato-Oncologic Diseases.Journal of clinical medicine · 2024Article
- Article
- Discovery and validation of circulating miRNAs for the clinical prognosis of severe dengue.PLoS neglected tropical diseases · 2022Article
- Dynamic Changes of Platelet and Factors Related Dengue Haemorrhagic Fever: A Retrospective Study in Indonesian.Diagnostics (Basel, Switzerland) · 2022Article
- The role of platelet transfusion in modulating platelet indices and leukocyte dynamics in dengue fever patients.Asian journal of transfusion scienceReview
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSome patients with dengue fever tend to develop thrombocytopenia during the course of infection and are thus vulnerable to haemorrhagic manifestations and other complications. However, the factors associated with the development of thrombocytopenia are unknown. We aimed to identify factors associated with an increased risk of thrombocytopenia and haematological changes in patients with confirmed dengue fever.
designRetrospective cohort study.
settingBrazilian multicentre primary care databases.
participants387 patients had positive laboratory serological confirmation of dengue infection during 2014. The data were identified from two databases: Notification of Injury Information System (SINAN) and Municipal Laboratory.
main outcome measureThe presence of thrombocytopenia (platelet count <1 50×10
resultsAmong 387 patients, 156 had both dengue and thrombocytopenia. The risk factors associated with thrombocytopenia included male sex (OR: 1.77, 95% CI: 1.16 to 2.71, p=0.007), age of 46-64 years (OR: 2.20, 95% CI: 1.15 to 4.21, p=0.009) or ≥65 years (OR: 3.02, 95% CI: 1.40 to 6.50, p=0.002), presence of leucopenia (OR: 6.85, 95% CI: 4.27 to 10.99, p<0.001) and high mean corpuscular haemoglobin (MCH) levels (OR: 2.00, 95% CI: 1.29 to 3.12, p=0.005).
conclusionOlder age, male sex, presence of leucopenia and high MCH levels were identified as risk factors associated with the development of thrombocytopenia in this population.
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