Evidence map›Paper›PMID 32928735›Full record

ArticleAntimicrobial agents and chemotherapy2020

Gallic and Ellagic Acids Are Promising Adjuvants to Conventional Amphotericin B for the Treatment of Cutaneous Leishmaniasis.

Michel Muálem de Moraes Alves, Daniel Dias Rufino Arcanjo, Kayo Alves Figueiredo, Jéssica Sara de Sousa Macêdo Oliveira, Felipe José Costa Viana, Elvilene de Sousa Coelho, Glaucia Lais Nunes Lopes, Juan Carlos Ramos Gonçalves, André Luís Menezes Carvalho, Márcia Dos Santos Rizzo and 3 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Human Lung Cancer (A549) Cell Line Cytotoxicity and Anti-Pharmaceuticals (Basel, Switzerland) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Michel Muálem de Moraes AlvesAntileishmanial Activity Laboratory, Medicinal Plants Research Center, Federal University of Piaui, Teresina, Piauí, Brazil mualemmichel@ufpi.edu.br.ORCID 0000-0003-4541-6096
Daniel Dias Rufino ArcanjoAntileishmanial Activity Laboratory, Medicinal Plants Research Center, Federal University of Piaui, Teresina, Piauí, Brazil.ORCID 0000-0001-7021-2744
Kayo Alves FigueiredoAntileishmanial Activity Laboratory, Medicinal Plants Research Center, Federal University of Piaui, Teresina, Piauí, Brazil.
Jéssica Sara de Sousa Macêdo OliveiraLaboratory of Natural Products, Department of Chemistry, Federal University of Piauí, Teresina, Piauí, Brazil.
Felipe José Costa VianaHistotechnical Laboratory, Department of Morphology, Federal University of Piauí, Teresina, Piauí, Brazil.
Elvilene de Sousa CoelhoLaboratory of Dermopharmacy, Faculty of Pharmacy, Federal University of Piauí, Teresina, Piauí, Brazil.
Glaucia Lais Nunes LopesLaboratory of Dermopharmacy, Faculty of Pharmacy, Federal University of Piauí, Teresina, Piauí, Brazil.
Juan Carlos Ramos GonçalvesAntileishmanial Activity Laboratory, Medicinal Plants Research Center, Federal University of Piaui, Teresina, Piauí, Brazil.
André Luís Menezes CarvalhoLaboratory of Dermopharmacy, Faculty of Pharmacy, Federal University of Piauí, Teresina, Piauí, Brazil.
Márcia Dos Santos RizzoHistotechnical Laboratory, Department of Morphology, Federal University of Piauí, Teresina, Piauí, Brazil.ORCID 0000-0003-4276-3113
Mariana Helena ChavesLaboratory of Natural Products, Department of Chemistry, Federal University of Piauí, Teresina, Piauí, Brazil.
Ivete Lopes de MendonçaDepartment of Veterinary Clinics and Surgery, Federal University of Piauí, Teresina, Piauí, Brazil.
Fernando Aécio de Amorim CarvalhoAntileishmanial Activity Laboratory, Medicinal Plants Research Center, Federal University of Piaui, Teresina, Piauí, Brazil.
Universidade Federal do Piauí · BRUniversidade Federal da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we demonstrated the potential associative effect of combining conventional amphotericin B (Amph B) with gallic acid (GA) and with ellagic acid (EA) in topical formulations for the treatment of cutaneous leishmaniasis in BALB/c mice. Preliminary stability tests of the formulations and

Indexed as

Amphotericin BAntiprotozoal AgentsEllagic AcidLeishmania majorLeishmaniasis, CutaneousAnimalsMiceMice, Inbred BALB CAmphotericin BAntiprotozoal AgentsEllagic Acidactivation of macrophagesdrug associationleishmaniasisphenolic compoundspoloxamer

Identifiers

PMID32928735
PMCPMC7674045
OpenAlexW3085023511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.