Evidence map›Paper›PMID 32928647›Full record

Observational studyNeuromuscular disorders : NMD2020

Optimizing hand-function patient outcome measures for inclusion body myositis.

Ava Yun Lin, Catherine Sly Siener, Anna V Faino, Michelle Seiffert, Conrad C Weihl, Leo H Wang

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neuromuscular disorders : NMD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Current biomarkers in inclusion body myositis.Journal of neuromuscular diseases · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ava Yun LinDepartment of Neurology, Stanford University, Stanford Neuroscience Health Center, 213 Quarry Road, M/C 5956, Palo Alto, CA 94305, Unted States.
Catherine Sly SienerDepartment of Neurology, Washington University in St. Louis, 660 S. Euclid, Campus Box 8111, St. Louis, MO 63110, Unted States.
Anna V FainoChildren's Core for Biomedical Statistics, Seattle Children's Research Institute, Seattle, WA, Unted States.
Michelle SeiffertDepartment of Neurology, Washington University in St. Louis, 660 S. Euclid, Campus Box 8111, St. Louis, MO 63110, Unted States.
Conrad C WeihlDepartment of Neurology, Washington University in St. Louis, 660 S. Euclid, Campus Box 8111, St. Louis, MO 63110, Unted States.
Leo H WangDepartment of Neurology, University of Washington Medical Center, Box 356465, 1959 NE Pacific Street. Seattle, WA 98195-6465, Unted States. Electronic address: leowang@uw.edu.

Funding

VCP in myopathy and dementiaR01AG031867 · NIA · WASHINGTON UNIVERSITY · PI CONRAD C WEIHL · 2009 to 2026
$9.1M
Clinical and Translational Studies in Muscle DiseaseK24AR073317 · NIAMS · WASHINGTON UNIVERSITY · PI CONRAD C WEIHL · 2018 to 2026
$1.6M
NIAMS NIH HHS K24 AR073317NIA NIH HHS R01 AG031867
6 · The paper itself

Abstract

Inclusion body myositis is the most commonly acquired myopathy after the age of 45. The slowly progressive and heterogeneous disorder is a challenge for measuring clinical trial efficacy. One current method for measuring progression utilizes the Inclusion Body Myositis-Functional Rating Scale. We have found that the upper extremity domain scores in the Inclusion Body Myositis-Functional Rating Scale do not consistently change until there is extreme loss of grip and finger flexor strength. Therefore, we performed a cross-sectional observational study of 83 inclusion body myositis patients and 38 controls recruited at the 2019 Annual Patient Conference of The Myositis Association. We evaluated new Inclusion Body Myositis Patient-Reported Outcome measures for upper extremity function modified from the NIH Patient-Reported Outcomes Measurement Information System as well as pinch and grip strength. We found that Patient-Reported Outcome measures hand-function have a higher correlation with pinch and grip strength than the Inclusion Body Myositis-Functional Rating Scale.

Indexed as

Functional StatusPatient Reported Outcome MeasuresSeverity of Illness IndexAgedCross-Sectional StudiesFemaleHand StrengthHumansMaleMiddle AgedMyositis, Inclusion BodyPinch StrengthFunctional rating scaleGrip strengthInclusion body myositisOutcome measuresPatient reported outcomePinch strength

Identifiers

PMID32928647
PMCPMC9756909

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.