Evidence map›Paper›PMID 32928621›Full record

ArticleSchizophrenia research2020

Factor structure of cognitive performance and functional capacity in schizophrenia: Evidence for differences across functional capacity measures.

Philip D Harvey, William P Horan, Alexandra S Atkins, Heather Stevens, Matthew Welch, Joshua Yuan, Thomas L Patterson, Meera Narasimhan, Richard S E Keefe

Open access · greenAbstract read
In one paragraph

Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  10. Computer-based virtual reality assessment of functional capacity in primary psychosis.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022
    Article
  11. Article
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  13. The Computerized Functional Skills Assessment and Training Program: Sensitivity to Global Cognitive Impairment, Correlations With Cognitive Abilities, and Factor Structure.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Philip D HarveyUniversity of Miami Miller School of Medicine, Research Service Bruce W. Cater VA Medical Center, Miami, FL, United States of America.
William P HoranVeraSci, Durham, NC, United States of America; University of California, Los Angeles, CA, United States of America.
Alexandra S AtkinsVeraSci, Durham, NC, United States of America.
Heather StevensVeraSci, Durham, NC, United States of America.
Matthew WelchVeraSci, Durham, NC, United States of America.
Joshua YuanVeraSci, Durham, NC, United States of America.
Thomas L PattersonUniversity of California, San Diego, CA, United States of America.
Meera NarasimhanUniversity of South Carolina, Columbia, SC, United States of America.
Richard S E KeefeVeraSci, Durham, NC, United States of America; Duke University, Durham, NC, United States of America. Electronic address: Richard.Keefe@duke.edu.
Verasci (United States) · USBruce W. Carter VA Medical Center · USUniversity of California, Los Angeles · USUniversity of California, San Diego · USUniversity of South Carolina · US

Funding

The Virtual Reality Functional Capacity Assessment Tool (VRFCAT) Validation StudyR44MH084240 · NIMH · VERASCI, LLC · PI ATKINS, ALEXANDRA STRICKLAND · 2012 to 2018
$3.4M
Computerized Interactive Assessment of Functional Skills for Schizophrenia Drug TR43MH084240 · NIMH · VERASCI, LLC · PI HURLEY, KOLLEEN, KEEFE, RICHARD S · 2009 to 2009
$137k
NIMH NIH HHS R43 MH084240NIMH NIH HHS R44 MH084240
6 · The paper itself

Abstract

backgroundCognition and functional capacity predict functional outcomes in mental illness. Traditional approaches conceptualize cognition as comprised of domains, but many studies support a unifactorial structure. Some functional capacity measures may share a single-factor structure with cognition. In this study, we examined the factor structure of two measures of functional capacity, a conventional assessment and a newer computerized assessment, testing for a shared factor structure with cognition.

methodsPatients with schizophrenia and healthy controls were examined with the MATRICS Consensus Cognitive Battery (MCCB), the UCSD Performance Based Skills Assessment (UPSA), and the Virtual Reality Functional Capacity Assessment Tool (VRFCAT). Models of the factor structures of the MCCB, UPSA, and VRFCAT were calculated, as were correlations between MCCB scores and individual VRFCAT objectives.

resultsThe MCCB, VRFCAT, and UPSA all had unifactorial structures. The best fitting model of the correlations between MCCB and UPSA was a shared single factor, while the best fit for the relationship between MCCB and VRFCAT had two factors. Correlations between the MCCB domain and composite scores and the VRFCAT objectives suggested global rather than specific patterns of correlation. DISCUSSION: The relationship between cognitive performance and functional capacity was found to vary across functional capacity assessments. The UPSA and MCCB were not differentiated into separate factors, suggesting that the UPSA may overlap with neurocognitive performance. However, the VRFCAT appears to measure functional abilities that are separable from, yet correlated with, neurocognitive performance. It may provide a more distinctive assessment of the functional capacity construct.

Indexed as

Cognition DisordersSchizophreniaActivities of Daily LivingCognitionHumansNeuropsychological TestsFunctional capacityNeurocognitionSchizophrenia

Identifiers

PMID32928621
PMCPMC7704623
OpenAlexW3086140336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.