Evidence map›Paper›PMID 32928300›Full record

ArticleHuman genomics2020

Long non-coding RNA MIR4300HG polymorphisms are associated with postoperative nausea and vomiting: a genome-wide association study.

Shigekazu Sugino, Daisuke Konno, Yosuke Kawai, Masao Nagasaki, Yasuhiro Endo, Tomo Hayase, Misako Yamazaki-Higuchi, Yukihiro Kumeta, Shunsuke Tachibana, Katsuhiko Saito and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Human genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Shigekazu SuginoDepartment of Anesthesiology and Perioperative Medicine, Tohoku University School of Medicine, Seiryo-machi 2-1, Sendai, Miyagi, 980-8575, Japan. shigekazu.sugino.d3@tohoku.ac.jp.ORCID 0000-0001-5748-6302
Daisuke KonnoDepartment of Anesthesiology and Perioperative Medicine, Tohoku University School of Medicine, Seiryo-machi 2-1, Sendai, Miyagi, 980-8575, Japan.
Yosuke KawaiDepartment of Integrative Genomics, Tohoku University Tohoku Medical Megabank Organization, Seiryo-machi 2-1, Sendai, Miyagi, 980-8575, Japan.
Masao NagasakiDepartment of Integrative Genomics, Tohoku University Tohoku Medical Megabank Organization, Seiryo-machi 2-1, Sendai, Miyagi, 980-8575, Japan.
Yasuhiro EndoDepartment of Anesthesiology and Perioperative Medicine, Tohoku University School of Medicine, Seiryo-machi 2-1, Sendai, Miyagi, 980-8575, Japan.
Tomo HayaseDepartment of Anesthesia, Otaru General Hospital, Wakamatsu 1, Otaru, Hokakido, 047-8550, Japan.
Misako Yamazaki-HiguchiDepartment of Anesthesia, Otaru General Hospital, Wakamatsu 1, Otaru, Hokakido, 047-8550, Japan.
Yukihiro KumetaDepartment of Anesthesia, Otaru General Hospital, Wakamatsu 1, Otaru, Hokakido, 047-8550, Japan.
Shunsuke TachibanaDepartment of Anesthesia, Otaru General Hospital, Wakamatsu 1, Otaru, Hokakido, 047-8550, Japan.
Katsuhiko SaitoDepartment of Pharmacy, Hokkaido Pharmaceutical University School of Pharmacy, Maeda 7-15, Sapporo, Hokakido, 006-8590, Japan.
Jun SuzukiDepartment of Anesthesiology and Perioperative Medicine, Tohoku University School of Medicine, Seiryo-machi 2-1, Sendai, Miyagi, 980-8575, Japan.
Kanta KidoDepartment of Anesthesiology, Kanagawa Dental University Graduate School of Dentistry, Inaoka 82, Yokosuka, Kanagawa, 238-8580, Japan.
Nahoko KurosawaDepartment of Pharmacy, Hokkaido Pharmaceutical University School of Pharmacy, Maeda 7-15, Sapporo, Hokakido, 006-8590, Japan.
Akiyoshi NamikiHospital Administrator, Otaru General Hospital, Wakamatsu 1, Otaru, Hokakido, 047-8550, Japan.
Masanori YamauchiDepartment of Anesthesiology and Perioperative Medicine, Tohoku University School of Medicine, Seiryo-machi 2-1, Sendai, Miyagi, 980-8575, Japan.
Tohoku University · JPOtaru Municipal Hospital · JPHokkaido Pharmaceutical University · JPKanagawa Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic factors such as single-nucleotide polymorphisms (SNPs) play a key role in the development of postoperative nausea and vomiting (PONV). However, previous findings are not widely applicable to different populations because of population-specific genetic variation. We developed a Japanese-specific DNA microarray for high-throughput genotyping. The aim of the current study was to identify SNPs associated with PONV on a genome-wide scale using this microarray in a sample of Japanese surgical patients.

methodsAssociations between 659,636 SNPs and the incidence of PONV 24 h after surgery in a limited sample of 24 female patients were assessed using the microarray. After imputation of genotypes at 24,330,529 SNPs, 78 SNPs were found to be associated with the incidence of PONV. We chose 4 of the 78 SNPs to focus on by in silico functional annotation. Finally, we genotyped these 4 candidate SNPs in 255 patients using real-time PCR to verify association with the incidence of PONV.

resultsThe T > C variant of rs11232965 in the long non-coding RNA MIR4300HG was significantly associated with reduced incidence of PONV among genotypes and between alleles (p = 0.01 and 0.007).

conclusionsWe identified a novel SNP (rs11232965) in the long non-coding RNA MIR4300HG that is associated with PONV. The rs11232965-SNP variant (T > C) is protective against the incidence of PONV.

trial registrationThis study was registered at the UMIN Clinical Trials Registry (Identifier: UMIN000022903 , date of registration: June 27, 2016, retrospectively registered.

Indexed as

Polymorphism, Single NucleotideAgedAged, 80 and overAllelesAsian PeopleCohort StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansIncidenceJapanMaleMiddle AgedRNA, Long NoncodingLong non-coding RNAPostoperative nausea and vomitingSingle-nucleotide polymorphism

Identifiers

PMID32928300
PMCPMC7491086
OpenAlexW3085276378

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.