Evidence map›Paper›PMID 32928299›Full record

ArticleBiology of sex differences2020

Role for ovarian hormones in purinoceptor-dependent natriuresis.

Eman Y Gohar, Malgorzata Kasztan, Shali Zhang, Edward W Inscho, David M Pollock

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sex differences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. GPER1 activation regulates renal purinergic P2YAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eman Y GoharDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA. emangohar@uabmc.edu.ORCID 0000-0003-0988-6445
Malgorzata KasztanDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA.
Shali ZhangDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA.
Edward W InschoDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA.
David M PollockDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA.
University of Alabama at Birmingham · US

Funding

Vascular and renal responses to stressP01HL069999 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI GEORGE, VARGHESE · 2002 to 2018
$31.1M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Research Supplement to Promote DiversityP01HL136267 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POLLOCK, DAVID M · 2017 to 2021
$11.9M
TLR4 in the Regulation of Renal Microvascular FunctionR01DK044628 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI INSCHO, EDWARD W · 2000 to 2021
$6.2M
The Role of Endothelin-1 in Tubular Injury in Sickle Cell DiseaseR00HL144817 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KASZTAN, MALGORZATA · 2021 to 2023
$747k
The role of endothelin-1 in tubular injury in sickle cell diseaseK99HL144817 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KASZTAN, MALGORZATA · 2019 to 2020
$306k
Sex Differences in Renal Sodium HandlingK99DK119413 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOHAR, EMAN · 2019 to 2020
$182k
NHLBI NIH HHS K99 HL144817NHLBI NIH HHS P01 HL069999NHLBI NIH HHS P01 HL136267NHLBI NIH HHS R00 HL144817NIDDK NIH HHS K99 DK119413NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK044628
6 · The paper itself

Abstract

backgroundPremenopausal women have a lower risk of hypertension compared to age-matched men and postmenopausal women. P2Y

methodsTo test our hypothesis, we determined (i) the effect of inhibiting medullary P2 receptors by suramin (750 μg/kg/min) on urinary Na

resultsAcute P2 inhibition attenuated urinary Na

conclusionThese data suggest that ovary-intact females have enhanced P2Y

Indexed as

AnimalsCell LineDose-Response Relationship, DrugEpithelial Sodium ChannelsEstradiolFemaleGene Expression RegulationKidney MedullaMaleNatriuresisOvariectomyOvaryRatsRats, Sprague-DawleyReceptors, Purinergic P2Receptors, Purinergic P2Y2Epithelial Sodium ChannelsEstradiolpurinoceptor P2Y4Receptors, Purinergic P2Receptors, Purinergic P2Y2RNA, MessengerSuraminType C PhospholipasesOvariectomyPurinoceptorsRenal medullaSodium excretion

Identifiers

PMID32928299
PMCPMC7490965
OpenAlexW3084666884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.