Evidence map›Paper›PMID 32928165›Full record

ArticleBMC musculoskeletal disorders2020

The incidence of stroke among selected patients undergoing elective posterior lumbar fusion: a retrospective cohort study.

Patrick J Arena, Jingping Mo, Charu Sabharwal, Elizabeth Begier, Xiaofeng Zhou, Alejandra Gurtman, Qing Liu, Rongjun Shen, Charles Wentworth, Kui Huang

Open access · goldAbstract read
In one paragraph

Article in BMC musculoskeletal disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Patrick J ArenaGlobal Medical Epidemiology & Big Data Analysis, Pfizer Inc, New York, NY, USA. patrick.arena@pfizer.com.ORCID https://orcid.org/0000-0003-3024-771X
Jingping MoSafety Surveillance Research, Pfizer Inc, New York, NY, USA.
Charu SabharwalVaccine Research & Development, Pfizer Inc, Pearl River, NY, USA.
Elizabeth BegierVaccine Research & Development, Pfizer Inc, Pearl River, NY, USA.
Xiaofeng ZhouGlobal Medical Epidemiology & Big Data Analysis, Pfizer Inc, New York, NY, USA.
Alejandra GurtmanVaccine Research & Development, Pfizer Inc, Pearl River, NY, USA.
Qing LiuGlobal Medical Epidemiology & Big Data Analysis, Pfizer Inc, Collegeville, PA, USA.
Rongjun ShenGlobal Medical Epidemiology & Big Data Analysis, Pfizer Inc, New York, NY, USA.
Charles WentworthGlobal Medical Epidemiology & Big Data Analysis, Pfizer Inc, New York, NY, USA.
Kui HuangGlobal Medical Epidemiology & Big Data Analysis, Pfizer Inc, New York, NY, USA.
Pfizer (United States) · US

Funding

Pfizer N/A
6 · The paper itself

Abstract

backgroundAlthough stroke is a rare complication among spinal surgery patients, the recognition of this adverse event is critical given the aging population undergoing surgical procedures. The objective of this study was to estimate the incidence of stroke among selected adults undergoing elective posterior lumbar fusion (PLF) during various post-operative risk windows and among different subgroups.

methodsA retrospective cohort study using a longitudinal electronic healthcare record (EHR) database was conducted from January 1, 2007 to June 30, 2018. Elective PLF, stroke, and select clinical characteristics were defined based on International Classification of Disease codes. Patients aged 18 to 85 years with ≥183 days of enrollment in the database prior to undergoing elective PLF were followed from the index date until the occurrence of stroke, death, loss to follow-up, or end of study period, whichever occurred first. The incidence of stroke was estimated in the following risk windows: index hospitalization, ≤ 30 days, ≤ 90 days, ≤ 180 days, and ≤ 365 days post-operation.

resultsA total of 43,063 patients were eligible for the study. The incidence of stroke following elective PLF was 0.29% (95% confidence interval [CI]: 0.25, 0.35%) during index hospitalization, 0.44% (95% CI: 0.38, 0.50%) ≤ 30 days, 0.59% (95% CI: 0.52, 0.67%) ≤ 90 days, 0.76% (95% CI: 0.68, 0.85%) ≤ 180 days, and 1.12% (95% CI: 1.03, 1.23%) ≤ 365 days post-operation. Stratified analyses revealed that older patients had a higher incidence of stroke. Additionally, black patients had higher stroke incidences. Post-operative stroke incidence was higher among patients with a history of type 2 diabetes than among patients without such history; similarly, stroke incidence was higher among patients with a history of stroke compared to patients without such history.

conclusionsThe incidence of stroke following elective PLF using an EHR database in this study is slightly higher than that reported in the literature. Our results suggest that stroke risk modification prior to PLF may be important for patients who are older, black, type 2 diabetic, and/or have a history of stroke.

Indexed as

Diabetes Mellitus, Type 2Spinal FusionStrokeAdolescentAdultAgedAged, 80 and overHumansIncidenceLumbar VertebraeMiddle AgedPostoperative ComplicationsRetrospective StudiesYoung AdultElectronic healthcare recordsEpidemiologyPosterior lumbar fusionStroke

Identifiers

PMID32928165
PMCPMC7488711
OpenAlexW3084472010

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.