ArticleThe journal of headache and pain2020
Haemodynamic activity characterization of resting state networks by fractal analysis and thalamocortical morphofunctional integrity in chronic migraine.
Article in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Fractal dynamics of the healthy human brain: A subcortical-to-cortical gradient of temporal complexity.iScience · 2026Article
- Spike dynamics in primate lateral prefrontal cortex during working memory and decision-making: A fractal analysis.iScience · 2026Article
- Diffusion Tensor Imaging-Based Glymphatic Dysfunction Assessments in Migraine Syndromes: Mechanisms and Diagnostic Implications.Biomedicines · 2025Review
- Temporal stability and neural complexity in resting-state MEG predict migraine phenotypes.The journal of headache and pain · 2025Article
- MRI-based analysis of the microstructure of the thalamus and hypothalamus and functional connectivity between cortical networks in episodic cluster headache.The journal of headache and pain · 2025Article
- Fractal Time Series: Background, Estimation Methods, and Performances.Advances in neurobiology · 2024Review
- Clinical Sensitivity of Fractal Neurodynamics.Advances in neurobiology · 2024Article
- Fractal Similarity of Pain Brain Networks.Advances in neurobiology · 2024Article
- Characterization of antiseizure medications effects on the EEG neurodynamic by fractal dimension.Frontiers in neuroscience · 2024Article
- Editorial: Methods and application in fractal analysis of neuroimaging data.Frontiers in human neuroscience · 2024Article
- A Hypothalamic Mechanism Regulates the Duration of a Migraine Attack: Insights from Microstructural and Temporal Complexity of Cortical Functional Networks Analysis.International journal of molecular sciences · 2022Article
- Region-specific complexity of the intracranial EEG in the sleeping human brain.Scientific reports · 2022Article
- Diagnostic Developments in Differentiating Unresponsive Wakefulness Syndrome and the Minimally Conscious State.Frontiers in neurology · 2021Review
- Gray and white matter abnormalities in primary trigeminal neuralgia with and without neurovascular compression.The journal of headache and pain · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic migraine (CM) can be associated with aberrant long-range connectivity of MRI-derived resting-state networks (RSNs). Here, we investigated how the fractal dimension (FD) of blood oxygenation level dependent (BOLD) activity may be used to estimate the complexity of RSNs, reflecting flexibility and/or efficiency in information processing in CM patients respect to healthy controls (HC).
methodsResting-state MRI data were collected from 20 untreated CM without history of medication overuse and 20 HC. On both groups, we estimated the Higuchi's FD. On the same subjects, fractional anisotropy (FA) and mean diffusivity (MD) values of bilateral thalami were retrieved from diffusion tensor imaging and correlated with the FD values.
resultsCM showed higher FD values within dorsal attention system (DAS) and the anterior part of default-mode network (DMN), and lower FD values within the posterior DMN compared to HC. Although FA and MD were within the range of normality, both correlated with the FD values of DAS.
conclusionsFD of DAS and DMN may reflect disruption of cognitive control of pain in CM. Since the normal microstructure of the thalamus and its positive connectivity with the cortical networking found in our CM patients reminds similar results obtained assessing the same structures but with the methods of neurophysiology, in episodic migraine during an attack, this may be yet another evidence in supporting CM as a never-ending migraine attack.
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