Evidence map›Paper›PMID 32928051›Full record

ArticleInternational journal of STD & AIDS2020

Incidence and clearance of penile human papillomavirus infection among circumcised Kenyan men.

Danielle M Backes, Claire Bosire, Michael G Hudgens, Ali Fokar, Kawango Agot, Felix Opiyo, Stephen Moses, Chris Jlm Meijer, Robert C Bailey, Peter Jf Snijders and 1 more

Open access · greenAbstract read
In one paragraph

Article in International journal of STD & AIDS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Danielle M BackesDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Claire BosireDepartment of Health Behavior, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-0229-7322
Michael G HudgensDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Ali FokarDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Kawango AgotImpact Research and Development Organization, Kisumu, Kenya.
Felix OpiyoNyanza Reproductive Health Society, Kisumu, Kenya.
Stephen MosesDepartment of Community Health Sciences, University of Manitoba, Winnipeg, Canada.
Chris Jlm MeijerDepartment of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
Robert C BaileyDivision of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, IL, USA.
Peter Jf SnijdersDepartment of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
Jennifer S SmithDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USAmsterdam UMC Location Vrije Universiteit Amsterdam · NLImpact Research and Development Organization · KENyanza Reproductive Health Society · KEUniversity of Illinois Chicago · USUniversity of Manitoba · CA

Funding

Trial of Male Circumcision to Reduce HIV IncidenceU01AI050440 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BAILEY, ROBERT CONVERSE · 2001 to 2009
$14.7M
DevelopmentalP30AI082151 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI LANDAY, ALAN L · 2009 to 2014
$4.6M
Cancer Health Disparities Training ProgramT32CA128582 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ENG, EUGENIA, TATE, DEBORAH F. · 2009 to 2023
$3.4M
Effect of Male Circumcision on Penile HPV InfectionR01CA114773 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SMITH, JENNIFER SUSAN · 2005 to 2010
$2.1M
NCI NIH HHS R01 CA114773NCI NIH HHS T32 CA128582NIAID NIH HHS P30 AI082151NIAID NIH HHS U01 AI050440
6 · The paper itself

Abstract

Prospective data are limited on human papillomavirus (HPV) acquisition and clearance among circumcised men from resource-limited geographical regions, particularly Africa. The goal of this study was to estimate incidence and clearance of type-specific genital HPV infection in men. Penile exfoliated cell specimens were collected from the glans/coronal sulcus and shaft of 1,037 circumcised Kenyan men at baseline and 6-, 12- and 18-month follow-up visits between 2003-2007. Specimens were tested with GP5+/6+ PCR to detect 44 HPV types. The median age of participants at baseline was 21 years (range 18-28). The 12- and 18-month incidence rates (IRs) for any HPV were 34.9/100 person-years (95% confidence interval [CI]: 31.2-39.0) and 36.4/100 person-years (95% CI: 32.9-40.2), respectively. The 18-month cumulative risk for high-risk HPV was 30% compared to 16% for low-risk HPV. Cumulative risk was not associated with age or anatomical site. The estimated probability of any HPV infection clearing by 12 months was 0.92. Time until HPV clearance was not associated with age, anatomical site, or whether HPV infection type was high-risk or low-risk. HPV IRs among circumcised men in this study were comparable to other circumcised populations.

Indexed as

Circumcision, MaleAdolescentAdultHumansIncidenceKenyaMalePapillomaviridaePapillomavirus InfectionsPenile DiseasesPenisPolymerase Chain ReactionSexually Transmitted DiseasesYoung AdultAfricacircumcisionHuman papillomavirusmen

Identifiers

PMID32928051
PMCPMC11391926
OpenAlexW3087322045

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.