Evidence map›Paper›PMID 32928039›Full record

ArticleJournal of the American Heart Association2020

Life's Simple 7 and Incident Hypertension: The REGARDS Study.

Timothy B Plante, Insu Koh, Suzanne E Judd, George Howard, Virginia J Howard, Neil A Zakai, John N Booth, Monika M Safford, Paul Muntner, Mary Cushman

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In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Timothy B PlanteDepartment of Medicine Larner College of Medicine at the University of Vermont Burlington VT.
Insu KohDepartment of Pathology and Laboratory Medicine Larner College of Medicine at the University of Vermont Burlington VT.
Suzanne E JuddDepartment of Biostatistics University of Alabama at Birmingham AL.
George HowardDepartment of Biostatistics University of Alabama at Birmingham AL.
Virginia J HowardDepartment of Epidemiology University of Alabama at Birmingham AL.
Neil A ZakaiDepartment of Medicine Larner College of Medicine at the University of Vermont Burlington VT.
John N BoothDepartment of Epidemiology University of Alabama at Birmingham AL.
Monika M SaffordDepartment of Medicine Weill Medical College of Cornell University New York NY.
Paul MuntnerDepartment of Epidemiology University of Alabama at Birmingham AL.
Mary CushmanDepartment of Medicine Larner College of Medicine at the University of Vermont Burlington VT.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

Background The Life's Simple 7 (LS7) metric incorporates health behaviors (body mass index, diet, smoking, physical activity) and health factors (blood pressure, cholesterol, glucose) to estimate an individual's level of cardiovascular health. The association between cardiovascular health and incident hypertension is unresolved. Hypertension's threshold was recently lowered and it is unclear if better cardiovascular health is associated with lower risk of incident hypertension with the updated threshold or in a multirace cohort. We sought to assess the association between better LS7 score and risk of incident hypertension among Black and White adults using a 130/80 mm Hg hypertension threshold. Methods and Results We determined the association between LS7 metric and incident hypertension in the REGARDS (Reasons for Geographic and Racial Disparities in Stroke) study, including participants free of baseline hypertension (2003-2007) who completed a second visit between 2013 and 2016. Hypertension was defined as systolic/diastolic blood pressure ≥130/80 mm Hg or antihypertensive medication use. Each LS7 component was assigned 0 (poor), 1 (intermediate), or 2 (ideal) points. We generated a 14-point score by summing points. Among 2930 normotensive participants (20% Black, 80% White), the median (25th-75th percentiles) LS7 total score was 9 (8-10) points. Over a median follow-up of 9 years, 42% developed hypertension. In the fully adjusted model, each 1-point higher LS7 score had a 6% lower risk of incident hypertension (risk ratio, 0.94 per 1 point; 95% CI, 0.92-0.96). Conclusions Better cardiovascular health was associated with lower risk of incident hypertension using a 130/80 mm Hg hypertension threshold among Black and White adults.

Indexed as

Health BehaviorBlack or African AmericanCardiovascular DiseasesFemaleHumansHypertensionIncidenceMaleMiddle AgedPrevalenceRisk FactorsRisk Reduction BehaviorUnited StatesWhite Peoplecardiovascular healthcohort studyhypertensionLife’s Simple 7

Identifiers

PMID32928039
PMCPMC7792383

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.