Evidence map›Paper›PMID 32928028›Full record

ArticleJournal of neurotrauma2020

Functional and Structural Neuroimaging Correlates of Repetitive Low-Level Blast Exposure in Career Breachers.

James R Stone, Brian B Avants, Nicholas J Tustison, Eric M Wassermann, Jessica Gill, Elena Polejaeva, Kristine C Dell, Walter Carr, Angela M Yarnell, Matthew L LoPresti and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 73 citations in OpenAlex.

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  15. Impact of repeated blast exposure on active-duty United States Special Operations Forces.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 3 countries.

James R StoneDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
Brian B AvantsDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
Nicholas J TustisonDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
Eric M WassermannBehavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA.
Jessica GillTissue Injury Branch, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA.
Elena PolejaevaDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
Kristine C DellDepartment of Psychology, Pennsylvania State University, University Park, Pennsylvania, USA.
Walter CarrOak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA.
Angela M YarnellMilitary Emergency Medicine, Uniformed Services University, Bethesda, Maryland, USA.
Matthew L LoPrestiCenter for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Peter WalkerHealth Mission Initiative, DoD Joint Artificial Intelligence Center, Washington, DC, USA.
Meghan O'BrienDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
Natalie DomeisenDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
Alycia QuickSchool of Psychology, University of Glasgow, Glasgow, United Kingdom.
Claire M ModicaNeurotrauma Department, Naval Medical Research Center, Silver Spring, Maryland, USA.
John D HughesBehavioral Biology Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Francis J HaranOperational and Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, Maryland, USA.
Carl GoforthOperational and Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, Maryland, USA.
Stephen T AhlersOperational and Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, Maryland, USA.
University of Virginia · USNaval Medical Research Command · USWalter Reed Army Institute of Research · USArtificial Intelligence in Medicine (Canada) · CANational Institute of Neurological Disorders and Stroke · USNational Institutes of Health · USOak Ridge Associated Universities · USPennsylvania State University · USUniformed Services University of the Health Sciences · USUniversity of Florida Health · USUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combat military and civilian law enforcement personnel may be exposed to repetitive low-intensity blast events during training and operations. Persons who use explosives to gain entry (i.e., breach) into buildings are known as "breachers" or dynamic entry personnel. Breachers operate under the guidance of established safety protocols, but despite these precautions, breachers who are exposed to low-level blast throughout their careers frequently report performance deficits and symptoms to healthcare providers. Although little is known about the etiology linking blast exposure to clinical symptoms in humans, animal studies demonstrate network-level changes in brain function, alterations in brain morphology, vascular and inflammatory changes, hearing loss, and even alterations in gene expression after repeated blast exposure. To explore whether similar effects occur in humans, we collected a comprehensive data battery from 20 experienced breachers exposed to blast throughout their careers and 14 military and law enforcement controls. This battery included neuropsychological assessments, blood biomarkers, and magnetic resonance imaging measures, including cortical thickness, diffusion tensor imaging of white matter, functional connectivity, and perfusion. To better understand the relationship between repetitive low-level blast exposure and behavioral and imaging differences in humans, we analyzed the data using similarity-driven multi-view linear reconstruction (SiMLR). SiMLR is specifically designed for multiple modality statistical integration using dimensionality-reduction techniques for studies with high-dimensional, yet sparse, data (i.e., low number of subjects and many data per subject). We identify significant group effects in these data spanning brain structure, function, and blood biomarkers.

Indexed as

AdultBlast InjuriesBrainBrain Injuries, TraumaticHumansMaleMiddle AgedNeuroimagingbreacherscortical thicknessdiffusion tensor imagingfunctional MRIperfusion imagingSiMLR

Identifiers

PMID32928028
PMCPMC7703399
OpenAlexW3087319203

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.