Evidence map›Paper›PMID 32927910›Full record

ArticleViruses2020

Infection Dynamics of Swine Influenza Virus in a Danish Pig Herd Reveals Recurrent Infections with Different Variants of the H1N2 Swine Influenza A Virus Subtype.

Tarka Raj Bhatta, Pia Ryt-Hansen, Jens Peter Nielsen, Lars Erik Larsen, Inge Larsen, Anthony Chamings, Nicole B Goecke, Soren Alexandersen

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review of genome sequencing technologies in molecular characterization of influenza A viruses in swine.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tarka Raj BhattaGeelong Centre for Emerging Infectious Diseases, Geelong, VIC 3220, Australia.ORCID 0000-0002-8199-8444
Pia Ryt-HansenDepartment of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.
Jens Peter NielsenDepartment of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.
Lars Erik LarsenDepartment of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.ORCID 0000-0003-0730-5555
Inge LarsenDepartment of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.ORCID 0000-0003-4575-2241
Anthony ChamingsGeelong Centre for Emerging Infectious Diseases, Geelong, VIC 3220, Australia.ORCID 0000-0002-7762-4757
Nicole B GoeckeDepartment of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.ORCID 0000-0003-4948-9946
Soren AlexandersenGeelong Centre for Emerging Infectious Diseases, Geelong, VIC 3220, Australia.ORCID 0000-0002-5039-3178
University of Copenhagen · DKBarwon Health · AUDeakin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza A virus (IAV) in swine, so-called swine influenza A virus (swIAV), causes respiratory illness in pigs around the globe. In Danish pig herds, a H1N2 subtype named H1N2dk is one of the main circulating swIAV. In this cohort study, the infection dynamic of swIAV was evaluated in a Danish pig herd by sampling and PCR testing of pigs from two weeks of age until slaughter at 22 weeks of age. In addition, next generation sequencing (NGS) was used to identify and characterize the complete genome of swIAV circulating in the herd, and to examine the antigenic variability in the antigenic sites of the virus hemagglutinin (HA) and neuraminidase (NA) proteins. Overall, 76.6% of the pigs became PCR positive for swIAV during the study, with the highest prevalence at four weeks of age. Detailed analysis of the virus sequences obtained showed that the majority of mutations occurred at antigenic sites in the HA and NA proteins of the virus. At least two different H1N2 variants were found to be circulating in the herd; one H1N2 variant was circulating at the sow and nursery sites, while another H1N2 variant was circulating at the finisher site. Furthermore, it was demonstrated that individual pigs had recurrent swIAV infections with the two different H1N2 variants, but re-infection with the same H1N2 variant was also observed. Better understandings of the epidemiology, genetic and antigenic diversity of swIAV may help to design better health interventions for the prevention and control of swIAV infections in the herds.

Indexed as

AnimalsDenmarkGenetic VariationInfluenza A Virus, H1N2 SubtypeOrthomyxoviridae InfectionsPhylogenyReinfectionSwineantigenic diversityH1N2phylogenetic analysispig herdprevalenceswine influenza A virus (swIAV)

Identifiers

PMID32927910
PMCPMC7551734
OpenAlexW3084211808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.