Evidence map›Paper›PMID 32927892›Full record

ArticleInternational journal of molecular sciences2020

Seung-Hwan Seo, Sang-Gyun Kim, Ji-Hun Shin, Do-Won Ham, Eun-Hee Shin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Biomolecules & therapeutics · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Science advances · 2024
    Article
  14. Parasites revive hope for cancer therapy.European journal of medical research · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. A novel enemy of cancer: recent investigations into protozoan anti-tumor properties.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Seung-Hwan SeoDepartment of Tropical Medicine and Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul 03080, Korea.ORCID 0000-0002-8645-1966
Sang-Gyun KimDepartment of Tropical Medicine and Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul 03080, Korea.
Ji-Hun ShinDepartment of Tropical Medicine and Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul 03080, Korea.
Do-Won HamDepartment of Tropical Medicine and Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul 03080, Korea.
Eun-Hee ShinDepartment of Tropical Medicine and Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul 03080, Korea.ORCID 0000-0003-1215-1079
Seoul National University · KR

Funding

Basic Science Research Program of the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology NRF-2018R1D1A1B07050517Seoul National University Bundang Hospital Research Fund 02-2018-010
6 · The paper itself

Abstract

Nuclear factor kappa B (NF-κB) activation is a well-known mechanism by which chemoresistance to anticancer agents is reported. It is well-known that irinotecan as a chemotherapeutic drug against non-small-cell lung carcinoma (NSCLC) has limited anticancer effect due to NF-κB activation. In this study, we propose the novel role of GRA16, a dense granule protein of

Indexed as

AnimalsAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Non-Small-Cell LungCell Line, TumorHumansIrinotecanLung NeoplasmsMiceNF-kappa BProtein Phosphatase 2Proto-Oncogene Proteins c-aktProtozoan ProteinsTopoisomerase I InhibitorsToxoplasmaXenograft Model Antitumor AssaysIrinotecanNF-kappa BProtein Phosphatase 2Proto-Oncogene Proteins c-aktProtozoan ProteinsTopoisomerase I Inhibitorsapoptosiscell cycle arrestGRA16-stable cell lineH1299irinotecanNF-κBnon-small-cell lung carcinoma cellsPP2A-B55Toxoplasma GRA16xenograft

Identifiers

PMID32927892
PMCPMC7554801
OpenAlexW3083974850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.