ReviewInternational journal of molecular sciences2020
Applying Single-Cell Analysis to Gonadogenesis and DSDs (Disorders/Differences of Sex Development).
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Comment on "FOXL2 expression in dysgenetic gonads supports the diagnostic possibility of ovotesticular differences of sex development".Virchows Archiv : an international journal of pathology · 2026Article
- Ambiguous genitalia in a male patient misidentified as female, leading to inappropriate circumcision: A rare case report.Radiology case reports · 2025Article
- Understanding testicular single cell transcriptional atlas: from developmental complications to male infertility.Frontiers in endocrinology · 2024Review
- The use ofSystems biology in reproductive medicine · 2023Article
- Article
- Overview of Avian Sex Reversal.International journal of molecular sciences · 2023Review
- Human development and reproduction in space-a European perspective.NPJ microgravity · 2023Review
- ATAC-seq and RNA-seq analysis unravel the mechanism of sex differentiation and infertility in sex reversal chicken.Epigenetics & chromatin · 2023Article
- Transcriptional control of human gametogenesis.Human reproduction update · 2022Article
- Resolving the Rules of Robustness and Resilience in Biology Across Scales.Integrative and comparative biology · 2022Article
- Fadrozole-mediated sex reversal in the embryonic chicken gonad involves a PAX2 positive undifferentiated supporting cell state.Frontiers in cell and developmental biology · 2022Article
- Becoming female: Ovarian differentiation from an evolutionary perspective.Frontiers in cell and developmental biology · 2022Review
- Ambiguous genitalia: clinical management of adult female with male assigned gender: a case report.Journal of medical case reports · 2021Article
- Establishing and maintaining fertility: the importance of cell cycle arrest.Genes & development · 2021Review
- Gonadal Sex Differentiation: Supporting Versus Steroidogenic Cell Lineage Specification in Mammals and Birds.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gonads are unique among the body's organs in having a developmental choice: testis or ovary formation. Gonadal sex differentiation involves common progenitor cells that form either Sertoli and Leydig cells in the testis or granulosa and thecal cells in the ovary. Single-cell analysis is now shedding new light on how these cell lineages are specified and how they interact with the germline. Such studies are also providing new information on gonadal maturation, ageing and the somatic-germ cell niche. Furthermore, they have the potential to improve our understanding and diagnosis of Disorders/Differences of Sex Development (DSDs). DSDs occur when chromosomal, gonadal or anatomical sex are atypical. Despite major advances in recent years, most cases of DSD still cannot be explained at the molecular level. This presents a major pediatric concern. The emergence of single-cell genomics and transcriptomics now presents a novel avenue for DSD analysis, for both diagnosis and for understanding the molecular genetic etiology. Such -omics datasets have the potential to enhance our understanding of the cellular origins and pathogenesis of DSDs, as well as infertility and gonadal diseases such as cancer.
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Registered trials
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