ArticleDiagnostic microbiology and infectious disease2020
A multiplex polymerase chain reaction assay for antibiotic stewardship in suspected pneumonia.
Article in Diagnostic microbiology and infectious disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Rapid commercial CTX-M diagnostics: Performance, limitations and clinical impact.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Diagnostic performance of Pneumonia multiplex PCR in critically ill immunocompromised patients.Critical care (London, England) · 2025Article
- Evaluation of the multiplex PCR combined with capillary electrophoresis technique for detecting pathogenic bacteria and antibiotic resistance genes in bone infections.BMC infectious diseases · 2025Article
- Impact of Respiratory Multiplex Polymerase Chain Reaction (PCR) on Antibiotic Stewardship: A Real-World Experience.Cureus · 2025Article
- Multiplex PCR Pneumonia Panel in Critically Ill Patients Did Not Modify Mortality: A Cohort Study.Antibiotics (Basel, Switzerland) · 2025Article
- Rapid Molecular Diagnostics of Pneumonia Caused by Gram-Negative Bacteria: A Clinician's Review.Antibiotics (Basel, Switzerland) · 2024Review
- The Challenges of The Diagnostic and Therapeutic Approach of Patients with Infectious Pathology in Emergency Medicine.Journal of personalized medicine · 2023Article
- Antibiotic De-Escalation in Critically Ill Patients with Negative Clinical Cultures.Pharmacy (Basel, Switzerland) · 2023Article
- Machine learning links unresolving secondary pneumonia to mortality in patients with severe pneumonia, including COVID-19.The Journal of clinical investigation · 2023Article
- ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia.Intensive care medicine · 2023Article
- Severe community-acquired pneumonia.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Urgent need for a rapid microbiological diagnosis in critically ill pneumonia.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022Review
- Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning.Nature medicine · 2022Article
- Evaluation of a Commercial Multiplexed Molecular Lower Respiratory Panel at a Tertiary Care Cancer Center.The Journal of molecular diagnostics : JMD · 2021Article
- Breathing Hope into Directed Therapy for Pulmonary Infections.American journal of respiratory and critical care medicine · 2021Article
- Multicenter Evaluation of the Unyvero Platform for Testing Bronchoalveolar Lavage Fluid.Journal of clinical microbiology · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundMultiplexed molecular rapid diagnostic tests (RDTs) may allow for rapid and accurate diagnosis of the microbial etiology of pneumonia. However, little data are available on multiplexed RDTs in pneumonia and their impact on clinical practice.
methodsThis retrospective study analyzed 659 hospitalized patients for microbiological diagnosis of suspected pneumonia.
resultsThe overall sensitivity of the Unyvero LRT Panel was 85.7% (95% CI 82.3-88.7) and the overall specificity was 98.4% (95% CI 98.2-98.7) with a negative predictive value of 97.9% (95% CI 97.6-98.1). The LRT Panel result predicted no change in antibiotics in 12.4% of cases but antibiotic de-escalation in 65.9% (405/615) of patients, of whom 278/405 (69%) had unnecessary MRSA coverage and 259/405 (64%) had unnecessary P. aeruginosa coverage.
interpretationIn hospitalized adults with suspected pneumonia, use of an RDT on respiratory samples can allow for early adjustment of initial antibiotics, most commonly de-escalation.
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