ReviewDevelopmental cognitive neuroscience2020
Cortical reorganization during adolescence: What the rat can tell us about the cellular basis.
Review in Developmental cognitive neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Cognitive and Pyroptotic Outcomes of Neonatal Ketamine and Dexmedetomidine: Potential Neuroprotection via Caspase-1 Modulation.Developmental neurobiology · 2026Article
- Differences related to sex in adolescent obese Zucker rats: locomotor activity and dendritic arborization of neurons in layer V of the primary motor cortex.Histochemistry and cell biology · 2026Article
- Impaired Synaptic Plasticity in a Rodent Model of Intimate Partner Violence-Related Brain Injury.Hippocampus · 2026Article
- Cognitive ability in childhood predicts adolescent structural and functional brain development: A longitudinal study.Developmental cognitive neuroscience · 2026Article
- Mechanical properties of the developing brain in a model of fetal alcohol spectrum disorders and relationships to perineuronal net integrity.Brain research · 2026Article
- Adolescent Social Isolation Induces Persistent Impairments in Emotional Discrimination and Helping Behavior.eNeuro · 2026Article
- The contributions of biological maturity and experience to fine motor development in adolescence.Scientific reports · 2026Article
- Brief antibiotics exposure during adolescence produces persistent effects on the microbiome and fentanyl-seeking during adulthood in rats.Frontiers in behavioral neuroscience · 2026Article
- Abnormal Magnetic Resonance Imaging in the Medial Prefrontal Cortex following Prenatal Alcohol Exposure and Placental Insufficiency in a Preclinical Model.Developmental neuroscience · 2025Article
- Emerging Adulthood Is Marked by a Cortical Dendritic Arborization Phase Depending on the Actin Nucleator Cobl.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hormonal contraceptives in adolescence impact the neuroimmune environment of the medial prefrontal cortex and hippocampus in female rats.Brain, behavior, and immunity · 2025Article
- Effects of Adolescent Social Isolation on PFC's β-Catenin Levels and Anxiety-Like Behaviors in Male and Female Rats: Study of the Role of Dopaminergic D2 Receptors.Journal of molecular neuroscience : MN · 2025Article
- Developing brain asymmetry shapes cognitive and psychiatric outcomes in adolescence.Nature communications · 2025Article
- Vibrotactile Stimulation in Lower Extremity Amputation Patients Using a Noninvasive Vibration Device: A Pilot Study.Plastic and reconstructive surgery. Global open · 2025Article
- Neurite development varies across the hippocampus and covaries with the cellular composition of hippocampal tissue.Communications biology · 2025Article
- The CB1 receptor: linking impulsivity and substance use disorder.Frontiers in neuroscience · 2025Review
- The neurostructural bases of empathy: morphometric evidence for a multicomponential approach.Frontiers in psychiatry · 2025Article
- Cells and Molecules Underpinning Cannabis-Related Variations in Cortical Thickness during Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Navigating Pubertal Goldilocks: The Optimal Pace for Hierarchical Brain Organization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Synaptic pruning during adolescence shapes adult social behavior in both males and females.Developmental psychobiology · 2024Article
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Authors and funding
2 authors.
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Abstract
The human cortex, particularly the prefrontal cortex, decreases in volume during adolescence which indicates considerable pruning. There is consistent evidence from human, monkey and rat tissue that synapses, dendritic spines and dendrites are pruned during this time. However, our work with a rat model of adolescence shows that other cellular components are remodeling at this time as well. Neurons are also pruned and we have found that in female rats, puberty is a key signal for this process. Other critical developmental events occur that are not detectable in gross size changes including the growth of dopaminergic inputs. The changes in the inhibitory GABAergic system, especially the parvalbumin-expressing neuronal subtype, are an essential part of the maturation of the prefrontal cortex. This involves the formation of perineuronal nets around parvalbumin interneurons that allow mature fast spiking. We have found a large increase in perineuronal nets from early adolescence to adulthood in both sexes. We also have seen a temporary pause in this increase at the time of puberty in females. These complicated events cannot be deduced from MRI. The cellular reorganization that is indicated by size changes in the human cortex during adolescence can be informed by work from rodent models.
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