ArticleNeuroImage. Clinical2020
Neural correlates of verbal working memory in children with epilepsy with centro-temporal spikes.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Executive functions and self-limited epilepsy with centro-temporal spikes: A scoping review.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Linking Cortical Morphometry in Self-Limited Epilepsy With Centrotemporal Spikes to Cognition, Function, and Molecular Architecture.CNS neuroscience & therapeutics · 2026Article
- Multidimensional dataset for cognitive assessment, sMRI, and rsfMRI in common benign epileptic children.Scientific data · 2025Article
- Structural and functional changes in drug-naïve benign childhood epilepsy with centrotemporal spikes and their associated gene expression profiles.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes.Life (Basel, Switzerland) · 2023Article
- Brain metabolic characteristics distinguishing typical and atypical benign epilepsy with centro-temporal spikes.European radiology · 2021Article
- Voxel-based and surface-based morphometric analyses reveal cortical-subcortical structural abnormalities and cognitive correlates in drug-naïve SeLECTS.Frontiers in neurologyArticle
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Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious functional magnetic resonance imaging (fMRI) studies have identified brain systems underlying different components of working memory (WM) in healthy subjects. The aim of this study was to compare the functional integrity of these neural networks in children with self-limited childhood epilepsy with centro-temporal spikes (ECTS) as compared to healthy controls, using a verbal working memory task (WMT).
methodsFunctional MRI of WM in seventeen 6-to-13 year-old children, diagnosed with ECTS, and 17 sex- and age-matched healthy controls were conducted at 3 T. To estimate BOLD responses during the maintenance of low, medium, and high WMT loads, we used a Sternberg verbal WMT. Neuropsychological testing prior to scanning and behavioral data during scanning were also acquired.
resultsBehavioral performances during WMT, in particular accuracy and response time, were poorer in children with ECTS than in controls. Increased WM load was associated with increased BOLD signal in all subjects, with significant clusters detected in frontal and parietal regions, predominantly in the left hemisphere. However, under the high load condition, patients showed reduced activation in the frontal, temporal and parietal regions as compared to controls. In brain regions where WM-triggered BOLD activation differed between groups, this activation correlated with neuropsychological performances in healthy controls but not in patients with ECTS, further suggesting WM network dysfunction in the latter.
conclusionChildren with ECTS differ from healthy controls in how they control WM processes during tasks with increasing difficulty level, notably for high WM load where patients demonstrate both reduced BOLD activation and behavioral performances.
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