ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2020
Scalp EEG interictal high frequency oscillations as an objective biomarker of infantile spasms.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Time-frequency characteristics of scalp high-frequency oscillations provide complementary biomarkers in infantile epileptic spasms syndrome.Experimental physiology · 2026Article
- Review
- Morphological Remodeling of Scalp High-Frequency Oscillations Across BASED-Stratified Groups in Infantile Epileptic Spasms Syndrome.Diagnostics (Basel, Switzerland) · 2026Article
- Prediction of treatment response in infantile epileptic spasms syndrome using EEG phase-amplitude coupling.Epilepsia open · 2026Article
- Scalp high-frequency activity differentiates neonates with seizures from healthy neonates and indicates postneonatal epilepsy risk.Epilepsia · 2026Article
- Phenotypic Classification of Scalp High-Frequency Oscillations in Absence Epilepsy Based on Multiple Characteristics Using K-Means Clustering.Bioengineering (Basel, Switzerland) · 2026Article
- Electrophysiological readout of ACTH-related neuroendocrine-immunomodulatory treatment response in infantile epileptic spasms syndrome: suppression of scalp ripple propagation networks.Frontiers in immunology · 2026Article
- PyHFO 2.0: an open-source platform for deep learning-based clinical high-frequency oscillations analysis.Journal of neural engineering · 2025Article
- AI-based localization of the epileptogenic zone using intracranial EEG.Epilepsia open · 2025Review
- Frontiers in EEG as a tool for the management of pediatric epilepsy: Past, present, and future.Epilepsia open · 2025Article
- Association Between Scalp High-Frequency Oscillations and Burden of Amplitudes and Epileptiform Discharges (BASED) Scores in Infantile Epileptic Spasms Syndrome.Biomolecules · 2025Article
- Article
- High-frequency oscillations in scalp EEG lateralize to the epileptogenic hemisphere in children and adults.Clinical neurophysiology practice · 2025Article
- Computational EEG attributes predict response to therapy for epileptic spasms.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- PyHFO: lightweight deep learning-powered end-to-end high-frequency oscillations analysis application.Journal of neural engineering · 2024Article
- EEG-based spatiotemporal dynamics of fast ripple networks and hubs in infantile epileptic spasms.Epilepsia open · 2024Article
- Scalp high-frequency oscillations differentiate neonates with seizures from healthy neonates.Epilepsia open · 2023Article
- Scalp HFO rates are higher for larger lesions.Epilepsia open · 2022Article
- Sevoflurane-based enhancement of phase-amplitude coupling and localization of the epileptogenic zone.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Different Frequency Bands in Various Regions of the Brain Play Different Roles in the Onset and Wake-Sleep Stages of Infantile Spasms.Frontiers in pediatrics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the diagnostic utility of high frequency oscillations (HFOs) via scalp electroencephalogram (EEG) in infantile spasms.
methodsWe retrospectively analyzed interictal slow-wave sleep EEGs sampled at 2,000 Hz recorded from 30 consecutive patients who were suspected of having infantile spasms. We measured the rate of HFOs (80-500 Hz) and the strength of the cross-frequency coupling between HFOs and slow-wave activity (SWA) at 3-4 Hz and 0.5-1 Hz as quantified with modulation indices (MIs).
resultsTwenty-three patients (77%) exhibited active spasms during the overnight EEG recording. Although the HFOs were detected in all children, increased HFO rate and MIs correlated with the presence of active spasms (p < 0.001 by HFO rate; p < 0.01 by MIs at 3-4 Hz; p = 0.02 by MIs at 0.5-1 Hz). The presence of active spasms was predicted by the logistic regression models incorporating HFO-related metrics (AUC: 0.80-0.98) better than that incorporating hypsarrhythmia (AUC: 0.61). The predictive performance of the best model remained favorable (87.5% accuracy) after a cross-validation procedure.
conclusionsIncreased rate of HFOs and coupling between HFOs and SWA are associated with active epileptic spasms. SIGNIFICANCE: Scalp-recorded HFOs may serve as an objective EEG biomarker for active epileptic spasms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.