Evidence map›Paper›PMID 32927180›Full record

ArticlePsychoneuroendocrinology2020

Psychological stress and cortisol during pregnancy: An ecological momentary assessment (EMA)-Based within- and between-person analysis.

Claudia Lazarides, Elizabeth Ben Ward, Claudia Buss, Wen-Pin Chen, Manuel C Voelkle, Daniel L Gillen, Pathik D Wadhwa, Sonja Entringer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Amygdala size varies with stress perception.Neurobiology of stress · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Claudia LazaridesCharité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Psychological Medicine, Germany.
Elizabeth Ben WardDepartment of Statistics, University of California, Irvine, CA, USA.
Claudia BussCharité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Psychological Medicine, Germany; Development, Health and Disease Research Program, University of California, Irvine, CA, USA; Department of Pediatrics, University of California, Irvine, CA, USA.
Wen-Pin ChenDepartment of Statistics, University of California, Irvine, CA, USA.
Manuel C VoelkleHumboldt-University of Berlin, Faculty of Life Science, Department of Psychology, Psychological Research Methods, Berlin, Germany.
Daniel L GillenDevelopment, Health and Disease Research Program, University of California, Irvine, CA, USA; Department of Statistics, University of California, Irvine, CA, USA.
Pathik D WadhwaDevelopment, Health and Disease Research Program, University of California, Irvine, CA, USA; Departments of Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, School of Medicine, University of California, Irvine, CA, USA. Electronic address: pwadhwa@uci.edu.
Sonja EntringerCharité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Psychological Medicine, Germany; Development, Health and Disease Research Program, University of California, Irvine, CA, USA; Department of Pediatrics, University of California, Irvine, CA, USA. Electronic address: sonja.entringer@charite.de.
University of California, Irvine · USCharité - Universitätsmedizin Berlin · DEFreie Universität Berlin · DEHumboldt-Universität zu Berlin · DE

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Pre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUH3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI Emily S Barrett, Richard Kermit Miller · 2018 to 2026
$15.9M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
Social Disadvantage and Fetal Programming of Newborn-Infant Telomere BiologyR01AG050455 · NIA · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI EPEL, ELISSA S., SIMHAN, HYAGRIV N · 2016 to 2020
$3.0M
Prenatal stress biology, infant body composition and obesity riskR01HD065825 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ENTRINGER, SONJA, WADHWA, PATHIK D · 2010 to 2014
$2.2M
NCATS NIH HHS UL1 TR001414NIA NIH HHS R01 AG050455NICHD NIH HHS R01 HD060628NICHD NIH HHS R01 HD065825NIH HHS UH3 OD023349
6 · The paper itself

Abstract

backgroundAlthough the linkage between psychological stress and cortisol is believed to mediate the association of stress with health outcomes, several studies have been unable to demonstrate this association. We suggest this inability may be a consequence of limitations in the measurement approach and/or reliance on analytic strategies that focus on associations across, rather than within individuals. The link between psychological stress and cortisol is of particular interest in the context of pregnancy and fetal development. Using an ecological momentary assessment (EMA) design, we examined the association between psychological stress and cortisol at the between- and the within-person level.

methods152 participants completed a 4-day long EMA protocol serially in early, mid and late pregnancy to provide momentary stress appraisals (average of 150 measures/subject) and saliva samples (average of 55 samples/subject) for quantification of cortisol. The association between stress and cortisol was estimated using linear mixed models.

resultsAfter accounting for the effects of key determinants of variation in cortisol, momentary stress was significantly and positively associated with cortisol at the within-person level (B = .030, p = .031), but not at the between-person level. No association was evident for traditional retrospective measures of stress with cortisol at either the between- or the within-person level.

conclusionsOur study highlights the value of EMA methods and linear mixed-modeling approaches in linking maternal psychological and physiological states across pregnancy. These findings may have important implications for the development of personalized risk identification and "just-in-time" intervention strategies to optimize maternal and child health.

Indexed as

AdultCaliforniaCohort StudiesEcological Momentary AssessmentFemaleHealthy VolunteersHumansHydrocortisoneHypothalamo-Hypophyseal SystemLinear ModelsLongitudinal StudiesPituitary-Adrenal SystemPregnancyRetrospective StudiesSalivaStress, PsychologicalHydrocortisoneCortisolEcological Momentary Assessment (EMA)Linear mixed modellingPregnancyPsychoendocrine covarianceStress

Identifiers

PMID32927180
PMCPMC7895320
OpenAlexW3080153437

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.