Evidence map›Paper›PMID 32926652›Full record

ArticleJournal of biopharmaceutical statistics2020

Continual reassessment method with regularization in phase I clinical trials.

Xiang Li, Anastasia Ivanova, Hong Tian, Pilar Lim, Kevin Liu

Abstract read
In one paragraph

Article in Journal of biopharmaceutical statistics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiang LiStatistics and Decision Sciences, Janssen Research & Development, LLC, Raritan, NJ, USA.ORCID 0000-0001-9790-5663
Anastasia IvanovaDepartment of Biostatistics, University of North Carolina at Chapel Hill, NC, USA.
Hong TianStatistics and Decision Sciences, Janssen Research & Development, LLC, Raritan, NJ, USA.
Pilar LimStatistics and Decision Sciences, Janssen Research & Development, LLC, Titusville, NJ, USA.
Kevin LiuBiostatistics, Genmab, Princeton, NJ, USA.

Funding

Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVIDIAN, MARIE, KOSOROK, MICHAEL R · 2010 to 2019
$21.3M
NCI NIH HHS P01 CA142538
6 · The paper itself

Abstract

Many Phase I trial designs have been developed to improve upon the standard

Indexed as

Clinical Trials, Phase I as TopicResearch DesignComputer SimulationDose-Response Relationship, DrugHumansMaximum Tolerated DoseProbabilityContinual reassessment methoddose-expansiondose-findingregularization

Identifiers

PMID32926652
PMCPMC7954799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.