Evidence map›Paper›PMID 32926651›Full record

ArticlePhysiological genomics2020

High-resolution analysis of differential gene expression during skeletal muscle atrophy and programmed cell death.

Junko Tsuji, Travis Thomson, Elizabeth Chan, Christine K Brown, Julia Oppenheimer, Carol Bigelow, Xianjun Dong, William E Theurkauf, Zhiping Weng, Lawrence M Schwartz

Open access · greenAbstract read
In one paragraph

Article in Physiological genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Junko TsujiProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts.
Travis ThomsonDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts.
Elizabeth ChanDepartment of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts.
Christine K BrownDepartment of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts.
Julia OppenheimerDepartment of Biology, Barnard College, New York, New York.
Carol BigelowDepartment of Biostatistics and Epidemiology, University of Massachusetts, Amherst, Massachusetts.
Xianjun DongProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts.
William E TheurkaufProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
Zhiping WengProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts.
Lawrence M SchwartzDepartment of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts.
University of Massachusetts Chan Medical School · USUniversity of Massachusetts Amherst · USBarnard College · US

Funding

RNA localization and translational controlR01HD049116 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI THEURKAUF, WILLIAM EDWARD · 2005 to 2024
$10.8M
Understanding the architecture, regulation, and function of piRNA-producing genesP01HD078253 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WENG, ZHIPING · 2015 to 2019
$6.5M
NICHD NIH HHS P01 HD078253NICHD NIH HHS P01HD078253NICHD NIH HHS R01 HD049116
6 · The paper itself

Abstract

Skeletal muscles can undergo atrophy and/or programmed cell death (PCD) during development or in response to a wide range of insults, including immobility, cachexia, and spinal cord injury. However, the protracted nature of atrophy and the presence of multiple cell types within the tissue complicate molecular analyses. One model that does not suffer from these limitations is the intersegmental muscle (ISM) of the tobacco hawkmoth

Indexed as

Genes, InsectTranscriptomeAmino Acid SequenceAnimalsApoptosisBase SequenceContractile ProteinsGene Expression ProfilingGene Expression RegulationManducaMicroRNAsMuscle ContractionMuscle, SkeletalMuscular AtrophyRNA, MessengerContractile ProteinsMicroRNAsRNA, MessengerautophagyManduca sextametamorphosisproteasomeubiquitin

Identifiers

PMID32926651
PMCPMC7750511
OpenAlexW3084924947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.