SynthesisJournal of endocrinological investigation2021
The association between hypoparathyroidism and cognitive impairment: a systematic review.
Synthesis in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Natural Course of Neuropsychological Functions in Chronic Non-Surgical Hypoparathyroidism on Conventional Therapy: 12 Years of Follow-Up.Calcified tissue international · 2026Observational
- Adult-onset pseudohypoparathyroidism type 1B diagnosed by methylation analysis: A case report and diagnostic considerations.Medicine · 2026Article
- Endocrine Disorders of Calcium Signaling in Children: Neuroendocrine Crosstalk and Clinical Implications.Cells · 2026Review
- Cognitive Function in Individuals with Chronic Hypoparathyroidism-A Prospective Observational Study.The Journal of clinical endocrinology and metabolism · 2025Observational
- PTH level might be associated with impaired quality of life in patients with nonsurgical hypoparathyroidism.Journal of endocrinological investigation · 2023Article
- Executive functioning in preschoolers with 22q11.2 deletion syndrome and the impact of congenital heart defects.Journal of neurodevelopmental disorders · 2023Article
- Skeletal and nonskeletal consequences of hypoparathyroidism.Archives of endocrinology and metabolism · 2022Review
- Serum calcium levels are associated with cognitive function in hypoparathyroidism: a neuropsychological and biochemical study in an Italian cohort of patients with chronic post-surgical hypoparathyroidism.Journal of endocrinological investigation · 2022Observational
- A Pilot Study of Cognition Among Hypoparathyroid Adults.Journal of the Endocrine Society · 2022Article
- The Russian Registry of Chronic Hypoparathyroidism.Frontiers in endocrinology · 2022Observational
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
context and purposeHypocalcemia and low parathyroid hormone levels have been commonly suggested as factors able to induce central nervous system disturbances. However, evidences on the occurrence of cognitive impairment are limited or underestimated. The aim of this review is, therefore, to systematically summarize the available evidence concerning the occurrence of cognitive impairment among subjects suffering from idiopathic or secondary hypoparathyroidism.
methodsA systematic selection of the available literature was performed by searching the online databases PubMed, Scopus and Web of Knowledge.
resultsThe present systematic review included sixteen case report articles and one cross-sectional controlled study. Case reports were the most representative literature sources and involved ten women and seven men. The presence of cognitive impairment was mostly discussed in association with idiopathic hypoparathyroidism (HPT); five articles described the occurrence of cognitive impairment following postsurgical HPT. The case-controlled study reported a significant presence of peculiar cognitive deficits (e.g. reduced inhibitory control, impairment in visuo-spatial functioning among, and psychomotor retardation) among HPT subjects compared to healthy controls, with serum total calcium and its product with phosphorus as independent predictors of neuropsychological dysfunctions.
conclusionEven though mostly based on single case reports, the presence of neuropsychological dysfunctions in the context of HPT appears to be a consistent core finding.
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