Evidence map›Paper›PMID 32926243›Full record

ArticleMedical oncology (Northwood, London, England)2020

Associated analysis of PER1/TUBB2B with endometrial cancer development caused by circadian rhythm disorders.

Zhaoxia Wang, Hui Wang, Zhaojun Wang, Simin He, Zhiping Jiang, Changping Yan, Sanyuan Zhang, Tong Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

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  12. Biological clock regulation by theFrontiers in cell and developmental biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhaoxia WangFirst Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan, 030001, Shanxi, China.
Hui WangSchool of Public Health, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Zhaojun WangSchool of Basic Medical Sciences, Shanxi Medical University, No. 29 Jiefang South Road, Taiyuan, 030001, Shanxi, China.
Simin HeSchool of Public Health, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Zhiping JiangFirst Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan, 030001, Shanxi, China.
Changping YanAffiliated Cancer Hospital of Shanxi Medical University, No. 3, Workers' New Village, Xinghualing District, Taiyuan, 030001, Shanxi, China.
Sanyuan ZhangFirst Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan, 030001, Shanxi, China. ffprofessor@126.com.
Tong WangSchool of Public Health, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. tongwang@sxmu.edu.cn.ORCID http://orcid.org/0000-0002-9403-7167
Shanxi Medical University · CN

Funding

Postdoctoral Research Foundation of China 2017M621107
6 · The paper itself

Abstract

Endometrial cancer (EC) is one of the most common gynecologic malignancies, and the incidence rate of night shift among women workers is higher than that in the general population. Circadian rhythm disorder, mainly rhythm gene, is related to various tumor onset, including EC. This study described the sleep/night-shift features of EC patients, explored the mechanism of the circadian clock gene PER and investigated prognostic and functional values of Per1 caused by night shift. A total of 619 subjects were enrolled and divided into two groups according to night-shift duties (rhythm group and control group), analyzed for clinical risk factors and night shift features of endometrial carcinoma. Then samples were randomly selected for sequencing and western blot were performed, and the function of overexpressed PER1 in ishikawa cells was explored. We noticed that severer EC patients experienced night-shift more frequently and with longer durations. A total of 58,174 differentially expressed genes were discovered, mainly rhythm genes and related to up and downstream regulatory genes. Western blot showed that the rhythm group had elevated protein expression of BCAS4, TUBB2B and RSPO4, and decreased expression of PER1 and PER2 in night-shift. In TCGA-EC datasets, PER1 was decreased in the EC patients with a significantly positive correlation with PER2, and higher PER1 expression indicated longer survival, opposite to TUBB2B. The research of overexpressing PER1 gene in EC ishikawa cells found that PER1 can promote apoptosis, expression of TNF-a, IL-6 and PD-1/PD-L1, inhibit the tumor invasion and expression of TUBB2B gene. Together, EC severity was associated with night-shift and rhythm disorders. The rhythm relating factors PER1, TUBB2B and tumor immune factors may regulate the mechanisms of EC onset and progression.

Indexed as

Endometrial NeoplasmsSleep Disorders, Circadian RhythmAdultAgedChronobiology DisordersFemaleGene Regulatory NetworksHumansMiddle AgedPeriod Circadian ProteinsTranscriptomeTubulinPER1 protein, humanPeriod Circadian ProteinsTUBB2B protein, humanTubulinCircadian rhythmECNext generation sequencingPER1TUBB2B

Identifiers

PMID32926243
OpenAlexW3085195630

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.