ArticleThe Journal of infectious diseases2021
Airway Gene Expression Correlates of Respiratory Syncytial Virus Disease Severity and Microbiome Composition in Infants.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 27 citations in OpenAlex.
- Early-life respiratory syncytial virus infection and asthma.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Unique nasal cell states induced by common pediatric respiratory viruses.bioRxiv : the preprint server for biology · 2026Article
- Mucosal IL-36 is a defining feature of severe paediatric bronchiolitis.Mucosal immunology · 2026Article
- RSV-NTHi Co-Infection Skews Host Immunity by Suppressing Type I IFN Responses and Enhancing Pro-Inflammatory Responses.Pathogens (Basel, Switzerland) · 2026Article
- Article
- Respiratory potentially pathogenic bacteria are associated with increased disease severity in neonates with respiratory syncytial virus infection.BMC infectious diseases · 2025Article
- DNA methylation signatures of severe RSV infection in infants: evidence from non-invasive saliva samples.Epigenetics & chromatin · 2025Article
- Nasal cathelicidin is expressed in early life and is increased during mild, but not severe respiratory syncytial virus infection.Scientific reports · 2024Article
- Targeted metagenomics reveals association between severity and pathogen co-detection in infants with respiratory syncytial virus.Nature communications · 2024Article
- Modeling Human Respiratory Syncytial Virus (RSV) Infection: Recent Contributions and Future Directions Using the Calf Model of Bovine RSV Disease.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- Sex-associated early-life viral innate immune response is transcriptionally associated with chromatin remodeling of type-I IFN-inducible genes.Mucosal immunology · 2023Article
- Transcriptome from Paired Samples Improves the Power of Comprehensive COVID-19 Host-Viral Characterization.International journal of molecular sciences · 2023Article
- Single cell transcriptomics identifies distinct profiles in pediatric acute respiratory distress syndrome.Nature communications · 2023Article
- Detailed characterization of Redondovirus in saliva of SARS-CoV-2-infected individuals in Sao Paulo, Brazil.PloS one · 2023Article
- Review
- COVID-19 as an infectome paradigm of autoimmunity.The Journal of allergy and clinical immunology · 2022Article
- Cilia-related gene signature in the nasal mucosa correlates with disease severity and outcomes in critical respiratory syncytial virus bronchiolitis.Frontiers in immunology · 2022Article
- The Upper Airway Microbiome and Lung Injury in COVID-19.American journal of respiratory and critical care medicine · 2021Article
- A systems genomics approach uncovers molecular associates of RSV severity.PLoS computational biology · 2021Article
- Metatranscriptomics to characterize respiratory virome, microbiome, and host response directly from clinical samples.Cell reports methods · 2021Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRespiratory syncytial virus (RSV) is the leading cause of severe respiratory disease in infants. The causes and correlates of severe illness in the majority of infants are poorly defined.
methodsWe recruited a cohort of RSV-infected infants and simultaneously assayed the molecular status of their airways and the presence of airway microbiota. We used rigorous statistical approaches to identify gene expression patterns associated with disease severity and microbiota composition, separately and in combination.
resultsWe measured comprehensive airway gene expression patterns in 106 infants with primary RSV infection. We identified an airway gene expression signature of severe illness dominated by excessive chemokine expression. We also found an association between Haemophilus influenzae, disease severity, and airway lymphocyte accumulation. Exploring the time of onset of clinical symptoms revealed acute activation of interferon signaling following RSV infection in infants with mild or moderate illness, which was absent in subjects with severe illness.
conclusionsOur data reveal that airway gene expression patterns distinguish mild/moderate from severe illness. Furthermore, our data identify biomarkers that may be therapeutic targets or useful for measuring efficacy of intervention responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.