Evidence map›Paper›PMID 32926075›Full record

SynthesisJAMA pediatrics2020

Association Between Maternal Perinatal Depression and Anxiety and Child and Adolescent Development: A Meta-analysis.

Alana Rogers, Shelley Obst, Samantha J Teague, Larissa Rossen, Elizabeth A Spry, Jacqui A Macdonald, Matthew Sunderland, Craig A Olsson, George Youssef, Delyse Hutchinson

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in JAMA pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 319 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
319citing papers in PubMed, 13 pooled it
36.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

319 citing papers in PubMed, 13 syntheses or guidelines pooled it, 545 citations in OpenAlex.

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259 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Alana RogersCentre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Deakin University, Geelong, Australia.
Shelley ObstCentre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Deakin University, Geelong, Australia.
Samantha J TeagueCentre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Deakin University, Geelong, Australia.
Larissa RossenNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.
Elizabeth A SpryCentre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Deakin University, Geelong, Australia.
Jacqui A MacdonaldCentre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Deakin University, Geelong, Australia.
Matthew SunderlandMatilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.
Craig A OlssonCentre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Deakin University, Geelong, Australia.
George YoussefCentre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Deakin University, Geelong, Australia.
Delyse HutchinsonCentre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Deakin University, Geelong, Australia.
Deakin University · AUThe University of Melbourne · AUMurdoch Children's Research Institute · AUThe University of Sydney · AUWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: There is widespread interest in associations between maternal perinatal depression and anxiety and offspring development; however, to date, there has been no systematic, meta-analytic review on the long-term developmental outcomes spanning infancy through adolescence. Objective: To provide a comprehensive systematic review and meta-analysis of the extant literature on associations between maternal perinatal depression and anxiety and social-emotional, cognitive, language, motor, and adaptability outcomes in offspring during the first 18 years of life. Data Sources: Six databases were searched (CINAHL Complete, Cochrane Library, Embase, Informit, MEDLINE Complete, and PsycInfo) for all extant studies reporting associations between perinatal maternal mental health problems and offspring development to March 1, 2020. Study Selection: Studies were included if they were published in English; had a human sample, quantitative data, a longitudinal design, and measures of perinatal depression and/or anxiety and social-emotional, cognitive, language, motor, and/or adaptability development in offspring; and investigated an association between perinatal depression or anxiety and childhood development. Data Extraction and Synthesis: Of 27 212 articles identified, 191 were eligible for meta-analysis. Data were extracted by multiple independent observers and pooled using a fixed- or a random-effects model. A series of meta-regressions were also conducted. Data were analyzed from January 1, 2019, to March 15, 2020. Main Outcomes and Measures: Primary outcomes included social-emotional, cognitive, language, motor, and adaptability development in offspring during the first 18 years of life. Results: After screening, 191 unique studies were eligible for meta-analysis, with a combined sample of 195 751 unique mother-child dyads. Maternal perinatal depression and anxiety were associated with poorer offspring social-emotional (antenatal period, r = 0.21 [95% CI, 0.16-0.27]; postnatal period, r = 0.24 [95% CI, 0.19-0.28]), cognitive (antenatal period, r = -0.12 [95% CI, -0.19 to -0.05]; postnatal period, r = -0.25 [95% CI, -0.39 to -0.09]), language (antenatal period, r = -0.11 [95% CI, -0.20 to 0.02]; postnatal period, r = -0.22 [95% CI, -0.40 to 0.03]), motor (antenatal period, r = -0.07 [95% CI, -0.18 to 0.03]; postnatal period, r = -0.07 [95% CI, -0.16 to 0.03]), and adaptive behavior (antenatal period, r = -0.26 [95% CI, -0.39 to -0.12]) development. Findings extended beyond infancy, into childhood and adolescence. Meta-regressions confirmed the robustness of the results. Conclusions and Relevance: Evidence suggests that perinatal depression and anxiety in mothers are adversely associated with offspring development and therefore are important targets for prevention and early intervention to support mothers transitioning into parenthood and the health and well-being of next-generation offspring.

Indexed as

AdolescentAnxietyChildChild DevelopmentChild, PreschoolCorrelation of DataDepressionFemaleHumansInfantMalePregnancy

Identifiers

PMID32926075
PMCPMC7490743
OpenAlexW3086442239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.