Evidence map›Paper›PMID 32925109›Full record

ReviewJournal of Parkinson's disease2020

The Universal Prescription for Parkinson's Disease: Exercise.

Jay L Alberts, Anson B Rosenfeldt

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Parkinson's disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04000360 nacompletednot on this map

Pragmatic Cyclical Lower Extremity Exercise Trial for Parkinson's Disease

TypeinterventionalSponsorThe Cleveland ClinicRan2019 to 2023Enrolled256ConditionsParkinson DiseaseArmsHigh-Intensity Aerobic Exercise (AE), Usual and Customary Care (UCC)
NCT06170866 nacompletednot on this mapstarted 2023, after this paper: background citation

Peer Partners to Improve Physical Activity in Older Latino and Latina Adults With Parkinson's Disease.

TypeinterventionalSponsorUConn HealthRan2023 to 2024Enrolled10ConditionsParkinson DiseaseArmsSocially supported physical activity
NCT06324422 narecruitingnot on this mapstarted 2024, after this paper: background citation

Can High-intensity Exercise be Used to Treat Fatigue in Parkinson´s Disease?

TypeinterventionalSponsorUniversity of AarhusRan2024 to 2026Enrolled94ConditionsParkinson's DiseaseArmsAerobic exercise intervention, Resistance exercise intervention
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  6. Lifestyle medicine for neuroprotection: evidence and implementation in Asian contexts.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jay L AlbertsCleveland Clinic, Department of Biomedical Engineering, Cleveland, OH, USA.
Anson B RosenfeldtCleveland Clinic, Department of Biomedical Engineering, Cleveland, OH, USA.

Funding

The Cyclical Lower-extremity Exercise for Parkinson's TrialR01NS073717 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI ALBERTS, JAY L. · 2011 to 2023
$4.8M
NINDS NIH HHS R01 NS073717
6 · The paper itself

Abstract

Over the past two decades, aerobic exercise has emerged as a mainstream recommendation to aid in treating Parkinson's disease (PD). Despite the acknowledgement of the benefits of exercise for people with PD (PwPD), frequently, exercise recommendations lack specificity in terms of frequency, intensity and duration. Additionally, conflating physical activity with exercise has contributed to providing vague exercise recommendations to PwPD. Therefore, the beneficial effects of exercise may not be fully realized in PwPD. Data provided by animal studies and select human trials indicate aerobic exercise may facilitate structural and functional changes in the brain. Recently, several large human clinical trials have been completed and collectively support the use of aerobic exercise, specifically high-intensity aerobic exercise, in improving PD motor symptoms. Data from these and other studies provide the basis to include aerobic exercise as an integral component in treating PD. Based on positive clinical findings and trials, it is advised that PwPD perform aerobic exercise in the following dose: 3x/week, 30-40-minute main exercise set, 60-80% of heart rate reserve or 70-85% of heart rate max. In lieu of heart rate, individuals can achieve an intensity of 14-17 on a 20-point RPE scale. Ongoing clinical trials, SPARX3 and CYCLE-II, have potential to further develop patient-specific exercise recommendations through prognostic modeling.

Indexed as

PrescriptionsAnimalsExerciseExercise TherapyHumansParkinson Diseaseaerobic exerciseexerciseParkinson’s diseasephysical activity

Identifiers

PMID32925109
PMCPMC7592674

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.