ArticleJournal of Alzheimer's disease : JAD2020
Cognitive, Genetic, Brain Volume, and Diffusion Tensor Imaging Markers as Early Indicators of Dementia.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- White matter hyperintensities volume and cognition: A meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Modeling Progressive Brain Volume Losses in Chronic Moderate Severe Traumatic Brain Injury: Extensive, but Attenuating.Annals of clinical and translational neurology · 2026Article
- Moderate tea consumption and dementia-related neuroimaging markers.Frontiers in neurology · 2025Article
- Article
- Pathways explaining racial/ethnic and socio-economic disparities in brain white matter integrity outcomes in the UK Biobank study.SSM - population health · 2024Article
- Bridging Reduced Grip Strength and Altered Executive Function: Specific Brain White Matter Structural Changes in Patients with Alzheimer's Disease.Clinical interventions in aging · 2024Article
- Development and internal validation of a prognostic model for 15-year risk of Alzheimer dementia in primary care patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Red cell distribution width, anemia and their associations with white matter integrity among middle-aged urban adults.Neurobiology of aging · 2021Article
- Correlation between changes in substructure diffusion tensor imaging and neurocognitive outcomes for pediatric brain tumor survivors.Neuro-oncology advancesArticle
- What's New in Dementia Risk Prediction Modelling? An Updated Systematic Review.Dementia and geriatric cognitive disorders extraReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough associated with dementia and cognitive impairment, microstructural white matter integrity is a rarely used marker of preclinical dementia.
objectiveWe aimed to evaluate the individual and combined effects of multiple markers, with special focus on microstructural white matter integrity, in detecting individuals with increased dementia risk.
methodsA dementia-free subsample (n = 212, mean age = 71.33 years) included in the population-based Swedish National Study on Aging and Care (SNAC-K) underwent magnetic resonance imaging (T1-weighted, fluid-attenuated inversion recovery, diffusion tensor imaging), neuropsychological testing (perceptual speed, episodic memory, semantic memory, letter and category fluency), and genotyping (APOE). Incident dementia was assessed during six years of follow-up.
resultsA global model (global cognition, APOE, total brain tissue volume: AUC = 0.920) rendered the highest predictive value for future dementia. Of the models based on specific markers, white matter integrity of the forceps major tract was included in the most predictive model, in combination with perceptual speed and hippocampal volume (AUC = 0.911).
conclusionAssessment of microstructural white matter integrity may improve the early detection of dementia, although the added benefit in this study was relatively small.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.