Observational studyJournal of Alzheimer's disease : JAD2020
Factors Associated with Lumbar Puncture Participation in Alzheimer's Disease Research.
Observational study in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 34 citations in OpenAlex.
- Examining the Decision to Take a Dementia Risk Test: Considerations for Privacy in Screening At-Home.Dementia and geriatric cognitive disorders · 2026Article
- Willingness and barriers to blood-based biomarker testing of Alzheimer's disease in the general population in the Czech Republic.Alzheimer's research & therapy · 2026Article
- Diabetes and Hypertension at Midlife Predict Increases in Biomarkers of Dementia Among Black Americans.Journal of racial and ethnic health disparities · 2026Article
- Sex differences in cerebral pulsatility and damping: A 4D flow MRI study.Experimental physiology · 2026Article
- Article
- WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study.Stroke · 2025Review
- Ethnic disparities in patients with early-onset Alzheimer's disease (EOAD).Frontiers in neurology · 2025Article
- Alzheimer's disease biomarkers and their current use in clinical research and practice.Molecular psychiatry · 2025Review
- Articulatory precision from connected speech as a marker of cognitive decline in Alzheimer's disease risk-enriched cohorts.Journal of Alzheimer's disease : JAD · 2025Article
- Impact of gender on the willingness to participate in clinical trials and undergo related procedures in individuals from an Alzheimer's prevention research cohort.Alzheimer's research & therapy · 2024Article
- Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease.Neurology · 2024Article
- The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core: A culturally informed, community-engaged research (CI-CER) model to advance brain health equity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- CSF Biomarkers in Longitudinal Alzheimer Disease Cohorts: Pre-Analytic Challenges.Clinical chemistry · 2024Article
- Inclusion of optic neuritis in dissemination in space improves the performance of McDonald 2017 criteria in Hispanic people with suspected multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Design and feasibility of an Alzheimer's disease blood test study in a diverse community-based population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Profiling baseline performance on the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort near the midpoint of data collection.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Intersectionality in Alzheimer's Disease: The Role of Female Sex and Black American Race in the Development and Prevalence of Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- "I Want to Know Everything ... ": The Return of Research Results and the Importance of Transparency in the Acceptability of Lumbar Punctures for African American Older Adults.Journal of Alzheimer's disease : JAD · 2023Article
- Screening and enrollment of underrepresented ethnocultural and educational populations in the Alzheimer's Disease Neuroimaging Initiative (ADNI).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Remote blood collection from older adults in the Brain Health Registry for plasma biomarker and genetic analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCerebrospinal fluid (CSF) provides insight into the spectrum of Alzheimer's disease (AD) pathology. While lumbar punctures (LPs) for CSF collection are generally considered safe procedures, many participants remain hesitant to participate in research involving LPs.
objectiveTo explore factors associated with participant willingness to undergo a research LP at baseline and follow-up research study visit.
methodsWe analyzed data from 700 participants with varying cognition (unimpaired, mild cognitive impairment, and dementia) in the Wisconsin Alzheimer's Disease Research Center. We evaluated the relationship of demographic variables (age, sex, race, ethnicity, and years of education) and clinical variables (waist-to-hip ratio, body mass index, AD parental history, cognitive diagnosis) on decision to undergo baseline LP1. We evaluated the relationship of prior LP1 experience (procedure success and adverse events) with the decision to undergo follow-up LP2. The strongest predictors were incorporated into regression models.
resultsOver half of eligible participants opted into both baseline and follow-up LP. Participants who underwent LP1 had higher mean education than those who declined (p = 0.020). White participants were more likely to choose to undergo LP1 (p < 0.001); 33% of African American participants opted in compared to 65% of white participants. Controlling for age, education, and AD parental history, race was the only significant predictor for LP1 participation. Controlling for LP1 mild adverse events, successful LP1 predicted LP2 participation.
conclusionRace was the most important predictor of baseline LP participation, and successful prior LP was the most important predictor of follow-up LP participation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.