ArticleJournal of Alzheimer's disease : JAD2020
Affective Neuropsychiatric Symptoms as Early Signs of Dementia Risk in Older Adults.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Towards a Multidimensional Model of Neurocognitive Disorders (MOND Model): Integrating Evidence from a Critical Review into a Model for Future Research.Journal of personalized medicine · 2026Review
- Mental health symptoms as preclinical indicators of dementia: a Whitehall II cohort study.medRxiv : the preprint server for health sciences · 2026Article
- Psychiatric Risk Factors for Progression From Mild Cognitive Impairment to Alzheimer's Disease: A Systematic Review.The American journal of geriatric psychiatry. Open science, education, and practice · 2025Article
- Depression exacerbates AD pathology through lactate-dependent activation of microglial Kv1.3 to promote Aβ-containing exosome spreading.Journal of neuroinflammation · 2025Article
- Cross-domain latent profiles of MCI and dementia are most differentiated by social and emotional functioning.Journal of the International Neuropsychological Society : JINS · 2025Article
- Behavioural and psychological symptoms among out-patients with different cognitive states: cross-sectional study.BJPsych open · 2025Article
- Development and content validity of the evaluation of multidimensional functioning and risks in aging scale.PeerJ · 2025Article
- Predictive regression models for cognitive impairment, dementia, and Alzheimer's disease using real-world electronic health records.Frontiers in neurology · 2025Article
- Associations between Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers in People with Mild Cognitive Impairment.Brain sciences · 2023Article
- The Synergic Effect of AT(N) Profiles and Depression on the Risk of Conversion to Dementia in Patients with Mild Cognitive Impairment.International journal of molecular sciences · 2023Article
- Decreased miR-451a in cerebrospinal fluid, a marker for both cognitive impairment and depressive symptoms in Alzheimer's disease.Theranostics · 2023Article
- Screening and Assessment for Alzheimer's Disease in the Days of Biological Biomarkers.Journal of Alzheimer's disease : JAD · 2023Article
- Visit-To-Visit Blood Pressure Variability and Subthreshold Depressive Symptoms in Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid?Alzheimer's research & therapy · 2022Article
- Prefrontal Aβ pathology influencing the pathway from apathy to cognitive decline in non-dementia elderly.Translational psychiatry · 2021Article
- Measuring neuropsychiatric symptoms in patients with early cognitive decline using speech analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- Trajectories of depression symptoms over time differ by APOE4 genotype in older adults with type 2 diabetes.International journal of geriatric psychiatry · 2021Article
- Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Impact of rehabilitation trajectory on affective and cognitive impairment after intracerebral hemorrhage: a cohort study.Frontiers in neurologyArticle
- A novel method for objective quantification of apathy based on gaze and physiological reactivity to stimuli presented in a virtual reality environment.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAffective neuropsychiatric symptoms (aNPS: depression, anxiety, apathy, irritability) have been linked to increased dementia risk. However, less is known whether this association is independent of Alzheimer's disease (AD) pathophysiology.
objectiveTo investigate the contribution of early aNPS to dementia risk in cognitively normal (CN) older adults and mild cognitive impairment (MCI) patients, with and without AD biomarker abnormality.
methodsParticipants included 763 community-dwelling, stroke-free older adults identified as CN and 617 with MCI at baseline, drawn from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Baseline assessments included a neuropsychological battery, the Neuropsychiatric Inventory (NPI), and apolipoprotein E ɛ4 (ApoE4) genotyping. A participant subset completed cerebrospinal fluid (CSF) AD biomarker assessment. Time to progression to dementia was measured based on months at follow-up when an individual was diagnosed with dementia, over the follow-up period of 48 months.
resultsLatent class analysis identified 3 subgroups of older adults in CN and MCI, indicated by the baseline profiles of neuropsychiatric symptoms (NPS). Subgroups with higher aNPS were at increased risk of progression to dementia in both CN (HR = 3.65, 95% CI [1.80, 7.40]) and MCI (HR = 1.52, 95% CI [1.16, 2.00]; HR = 1.86 [1.05, 3.30]) groups, adjusting for age, sex, global cognition, and ApoE4, compared with their counterparts with minimal NPS. There was no difference between higher aNPS and minimal NPS subgroups in their CSF AD biomarker profiles.
conclusionFindings suggest that aNPS may represent a neurobiological vulnerability that uniquely contribute to the dementia risk, independent of AD biomarker profiles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.