ArticleJournal of Alzheimer's disease : JAD2020
Brainstem Volumetric Integrity in Preclinical and Prodromal Alzheimer's Disease.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Altered locus coeruleus links to atrophy and hypometabolism in individuals with high Alzheimer's disease biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment.Brain : a journal of neurology · 2022Trial
- Brainstem volume and arterial stiffness interact to support memory in midlife.Brain imaging and behavior · 2026Article
- Recovery strategies during trip-like support surface perturbations while walking in older adults with mild cognitive impairment.GeroScience · 2026Article
- Neuromechanistic causes of timber falls in older adults with mild cognitive impairment: Is response initiation or motor execution the problem?GeroScience · 2026Article
- BOLD fMRI activations and LC contrast associated with successful episodic memory in healthy older adults and MCI.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion-Tensor-Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review.Journal of magnetic resonance imaging : JMRI · 2026Review
- Combined Effects of Vestibular Dysfunction and Mild Cognitive Impairment on Reactive Stepping Responses in Older Adults.Medicine and science in sports and exercise · 2026Article
- Emotional enhancement of memory in Alzheimer's disease dementia: a systematic review.Nature. Mental health · 2025Article
- Reductions in brainstem volume as a key macrostructural indicator in at-risk populations for Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei differs across the lifespan.GeroScience · 2025Article
- Shape Alterations of Subcortical Nuclei Correlate With Amyotrophic Lateral Sclerosis Progression.Brain and behavior · 2025Article
- Dual task reactive balance control in older adults with mild cognitive impairment: does the cognitive task domain make a difference?Journal of neurophysiology · 2025Article
- Monoamine alterations in Alzheimer's disease and their implications in comorbid neuropsychiatric symptoms.GeroScience · 2025Review
- Noradrenergic therapies in neurodegenerative disease: from symptomatic to disease modifying therapy?Brain communications · 2025Review
- Greater physical fitness (Acta physiologica (Oxford, England) · 2024Article
- Exploring the Role of Locus Coeruleus in Alzheimer's Disease: a Comprehensive Update on MRI Studies and Implications.Current neurology and neuroscience reports · 2023Review
- Repeated Methamphetamine Administration Results in Axon Loss Prior to Somatic Loss of Substantia Nigra Pars Compacta and Locus Coeruleus Neurons in Male but Not Female Mice.International journal of molecular sciences · 2023Article
- Altered structural covariance of locus coeruleus in individuals with significant memory concern and patients with mild cognitive impairment.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The knowledge domain of cognitive neuroscience of aging: A Scientometric and bibliometric analysis.Frontiers in aging neuroscience · 2023Review
Corrections and comments
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5 authors.
Funding
Abstract
backgroundNeuropathological studies have suggested the tau pathology observed in Alzheimer's disease (AD) originates in brainstem nuclei, but no studies to date have quantified brainstem volumes in clinical populations with biomarker-confirmed mild cognitive impairment (MCI) or dementia due to AD or determined the value of brainstem volumetrics in predicting dementia.
objectiveThe present study examined whether MRI-based brainstem volumes differ among cognitively normal older adults and those with MCI or dementia due to AD and whether preclinical brainstem volumes predict future progression to dementia.
methodsAlzheimer's Disease Neuroimaging Initiative participants (N = 1,629) underwent baseline MRI scanning with variable clinical follow-up (6-120 months). Region of interest and voxel-based morphometric methods assessed brainstem volume differences among cognitively normal (n = 814), MCI (n = 542), and AD (n = 273) participants, as well as subsets of cerebrospinal fluid biomarker-confirmed MCI (n = 203) and AD (n = 160) participants.
resultsMCI and AD cases showed smaller midbrain volumes relative to cognitively normal participants when normalizing to whole brainstem volume, and showed smaller midbrain, locus coeruleus, pons, and whole brainstem volumes when normalizing to total intracranial volume. Cognitively normal individuals who later progressed to AD dementia diagnosis exhibited smaller baseline midbrain volumes than individuals who did not develop dementia, and voxel-wise analyses revealed specific volumetric reduction of the locus coeruleus.
conclusionFindings are consistent with neuropathological observations of early AD-related pathology in brainstem nuclei and further suggest the clinical relevance of brainstem substructural volumes in preclinical and prodromal AD.
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