Evidence map›Paper›PMID 32924201›Full record

ArticleJournal of veterinary internal medicine2020

Risk factors for adverse events occurring after recovery from stereotactic brain biopsy in dogs with primary intracranial neoplasia.

Richard L Shinn, Yukitaka Kani, Fang-Chi Hsu, John H Rossmeisl

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Common Neurologic Diseases in Geriatric Dogs.Animals : an open access journal from MDPI · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Richard L ShinnVeterinary and Comparative Neuro-oncology Laboratory, Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.ORCID https://orcid.org/0000-0003-4308-4374
Yukitaka KaniVeterinary and Comparative Neuro-oncology Laboratory, Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.
Fang-Chi HsuDepartments of Biostatistical Sciences, Wake Forest University, Winston-Salem, North Carolina, USA.
John H RossmeislVeterinary and Comparative Neuro-oncology Laboratory, Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.ORCID https://orcid.org/0000-0003-1655-7076
Virginia–Maryland College of Veterinary Medicine · USWake Forest University · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Sub-component for Institution # 16-01848 Novel moleculary targeted therapy of GBMP01CA207206 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEBINSKI, WALDEMAR · 2017 to 2021
$9.0M
High-frequency Irreversible Electroporation (H-FIRE) combinatorial GBM treatmentR01CA213423 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI DAVALOS, RAFAEL VIDAL, VERBRIDGE, SCOTT S · 2017 to 2021
$1.7M
Molecular Combinatorial Therapy of Glioblastoma MultiformeR01CA139099 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEBINSKI, WALDEMAR · 2010 to 2014
$1.5M
NCI NIH HHS P01 CA207206NCI NIH HHS P01CA207206NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA139099NCI NIH HHS R01CA139099NCI NIH HHS R01 CA213423NCI NIH HHS R01CA213423
6 · The paper itself

Abstract

backgroundStereotactic brain biopsy (SBB) allows for histopathologic diagnosis of brain tumors. Adverse events (AE) occur in 5 to 29% of dogs after SBB, but risk factors associated with developing AE are poorly described.

objectiveIdentify clinicopathologic, diagnostic imaging, or procedural variables that are associated with AE in dogs after SBB. ANIMALS: Twenty-nine dogs with brain tumors.

methodsRetrospective, case-control study. Dogs had laboratory investigations performed before SBB, as well as clinical examinations and diagnostic imaging of the brain before and after SBB. Cases experienced AE after SBB including transient exacerbation of preexisting neurologic deficits, transient new deficits, or permanent neurologic deficits. Controls had SBB performed without AE. Fisher's exact and Student's t tests were used to examine associations between the postulated risk factors and AE.

resultsAdverse events occurred in 8/29 (27%) dogs, and 7/8 AE (88%) were transient. Cases were significantly more likely to have T2W-heterogenous tumors (88 versus 38%; P = .04) and lower platelet counts (194.75 ± 108.32 versus 284.29 ± 68.54 ×10 CONCLUSION AND CLINICAL IMPORTANCE: Twenty-seven percent of dogs undergoing SBB experience AE, with the majority of AE resolving with 1 week. Platelet counts should be ≥185 000/mm

Indexed as

Brain NeoplasmsDog DiseasesAnimalsBiopsyBrainCase-Control StudiesDogsRetrospective StudiesRisk FactorsStereotaxic Techniquesbrain tumorcaninediagnostic methodsneurosurgeryrisk factors

Identifiers

PMID32924201
PMCPMC7517515
OpenAlexW3085539516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.