SynthesisDiabetic medicine : a journal of the British Diabetic Association2021
Understanding the relationship between type 2 diabetes and depression: lessons from genetically informative study designs.
Synthesis in Diabetic medicine : a journal of the British Diabetic Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tools for assessing quality and risk of bias in Mendelian randomization studies: a systematic review.International journal of epidemiology · 2023Pooled it
- Psychological Care Needs and Mental Health Service Use Among Adults with Diabetes: Evidence from the Diabetes, Distress, and Disparities (3D) Study.Healthcare (Basel, Switzerland) · 2025Article
- An Analysis of Primary Hyperparathyroidism in Association with Depression or Anxiety.Diseases (Basel, Switzerland) · 2025Review
- Depression, anxiety, and health-related quality of life in normal weight, overweight and obese individuals with diabetes: a representative study in Germany.Acta diabetologica · 2024Article
- Associations of comorbid depression with cardiovascular-renal events and all-cause mortality accounting for patient reported outcomes in individuals with type 2 diabetes: a 6-year prospective analysis of the Hong Kong Diabetes Register.Frontiers in endocrinology · 2024Article
- Walking away from depression: the mediating role of walking activity in depression impacting blood glucose levels of people with diabetes or prediabetes.Frontiers in endocrinology · 2024Article
- Depression and type 2 diabetes risk: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Exploring the Interrelationships between Diabetes, Nutrition, Anxiety, and Depression: Implications for Treatment and Prevention Strategies.Nutrients · 2023Review
- Association between Serum Irisin and Leptin Levels and Risk of Depressive Symptoms in the Diabetic Elderly Population.Journal of clinical medicine · 2023Article
- Leveraging a genetically-informative study design to explore depression as a risk factor for type 2 diabetes: Rationale and participant characteristics of the Mood and Immune Regulation in Twins Study.Frontiers in clinical diabetes and healthcare · 2023Article
- Early-Onset Type 2 Diabetes and Mood, Anxiety, and Stress-Related Disorders: A Genetically Informative Register-Based Cohort Study.Diabetes care · 2022Article
- A pilot randomized clinical trial of tDCS for increasing exercise engagement in individuals with elevated depressive symptoms: Rationale, design, and baseline characteristics.Contemporary clinical trials communications · 2022Article
- No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study.Frontiers in immunology · 2022Article
- Is it time to consider depression as a major complication of type 2 diabetes? Evidence from a large population-based cohort study.Acta diabetologica · 2022Article
- Glucocorticoid Receptor Signaling in Diabetes.International journal of molecular sciences · 2021Review
- Improved Depression Symptoms Among Low-Income Mexican Americans Participating in a Community-Clinical Diabetes Intervention.Journal of primary care & community healthArticle
- Depression Exacerbates Hepatic Steatosis in C57BL/6J Mice by Activating the Hypothalamic-Pituitary-Adrenal Axis.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
aimsTo conduct a systematic review in order to comprehensively synthesize the findings from a diverse range of genetically informative studies on comorbid depression and type 2 diabetes.
methodsDatabase searches (1 January 2008 to 1 June 2020) in PubMed and EMBASE were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Eligible reports employed any type of genetically informed design, including twin modelling, Mendelian randomization, genome-wide association studies, polygenetic risk scores, or linkage disequilibrium score regression. Searches generated 451 unique citations, and 16 manuscripts met the inclusion criteria.
resultsThe included studies addressed three aetiological models of the depression-diabetes relationship: uni- or bi-directional phenotypic causation; shared genetic liability; or gene-environment interaction. From these studies, there is modest evidence that type 2 diabetes is causally related to risk of developing depression, but much more limited evidence that depression is causally related to risk of diabetes. There is little evidence of shared genetic liability between depression and diabetes or of gene-environment interaction.
conclusionsFindings from genetically informed studies are mixed but provide some support for the uni- or bi-directional phenotypic model of depression and type 2 diabetes. Future studies should also explore the hypothesis that this relationship may be influenced by shared environmental risk factors. Findings can inform multifaceted approaches to diabetes prevention and care that reflect how psychosocial factors contribute to type 2 diabetes risk and outcomes.
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