ReviewPediatric cardiology2020
Cardiac Surgery in Trisomy 13 and 18: A Guide to Clinical Decision-Making.
Review in Pediatric cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Appraisal of congenital heart disease guidelines and consensus.Frontiers in pediatrics · 2026Pooled it
- Recognition of Patau Syndrome (Trisomy 13) Based on Clinical Features in a Resource-Limited Setting: A Case Report.Clinical case reports · 2026Article
- Survival Benefit and Persistent Hospitalization Burden After Ventricular Septal Defect Closure in Infants with Trisomy 18 Headings: Hospitalization After VSD Closure in Trisomy 18.Pediatric cardiology · 2026Article
- Current prenatal counseling of congenital heart disease in trisomy 18, pediatric cardiologists' perspective: a Fetal Heart Society Research Collaborative Study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Closure of ventricular septal defect in children with trisomy 18: perioperative events and long-term survival.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Trisomy 18 and the possibility of choice: The importance of Perinatal Hospice's support.European journal of pediatrics · 2025Article
- Prevalence and clinical characterization of oral clefts in patients with chromosome trisomy 18.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2024Article
- Effect of cardiac surgery on survival in patients with trisomy 18: A single-center experience.Turk gogus kalp damar cerrahisi dergisi · 2023Article
- Patau and Edwards Syndromes in a University Hospital: beyond palliative care.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023Article
- Trisomy 13: Survival beyond the NICU.NeoReviews · 2023Article
- Article
- Misdiagnosis of trisomy 13 and trisomy 18 is more common than anticipated.American journal of medical genetics. Part A · 2022Article
- The current state of prenatal detection of genetic conditions in congenital heart defects.Translational pediatrics · 2021Review
- Trisomy 13 as a risk factor for pulmonary hypertension induced by diazoxide.Annals of pediatric cardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been substantial controversy regarding treatment of congenital heart defects in infants with trisomies 13 and 18. Most reports have focused on surgical outcomes versus expectant treatment, and rarely there has been an effort to consolidate existing evidence into a more coherent way to help clinicians with decision-making and counseling families. An extensive review of the existing literature on cardiac surgery in patients with these trisomies was conducted from 2004 to 2020. The effects of preoperative and perioperative factors on in-hospital and long-term mortality were analyzed, as well as possible predictors for postoperative chronic care needs such as tracheostomy and gastrostomy. Patients with minimal or no preoperative pulmonary hypertension and mechanical ventilation undergoing corrective surgery at a weight greater than 2.5 kg suffer from lower postoperative mortality. Infants with lower-complexity cardiac defects are likely to benefit the most from surgery, although their expected mortality is higher than that of infants without trisomy. Omphalocele confers an increased mortality risk regardless of cardiac surgery. Gastrointestinal comorbidities increased the risk of gastrostomy tube placement, while those with prolonged mechanical ventilation and respiratory comorbidities are more likely to require tracheostomy. Cardiac surgery is feasible in children with trisomies 13 and 18 and can provide improved long-term results. However, this is a clinically complex population, and both physicians and caretakers should be aware of the long-term challenges these patients face following surgery when discussing treatment options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.