Evidence map›Paper›PMID 32923908›Full record

ArticleJCO precision oncology2020

Clinical Relevance of an Amplicon-Based Liquid Biopsy for Detecting

Laura Mezquita, Aurélie Swalduz, Cécile Jovelet, Sandra Ortiz-Cuaran, Karen Howarth, David Planchard, Virginie Avrillon, Gonzalo Recondo, Solène Marteau, Jose Carlos Benitez and 20 more

Abstract read
In one paragraph

Article in JCO precision oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Case Report:Frontiers in oncology · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Liquid Biopsy in Solid Tumours: An Overview.Cytopathology : official journal of the British Society for Clinical Cytology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. A narrative review of methods for the identification ofTranslational lung cancer research · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Laura MezquitaCancer Medicine Department, Gustave Roussy, Villejuif, France.
Aurélie SwalduzDepartment of Medical Oncology, Centre Léon Bérard Lyon, France.
Cécile JoveletPlateforme de Génomique, Module de Biopathologie Moléculaire et Centre de Ressources Biologiques, AMMICa, INSERM US23/CNRS UMS3655, Gustave Roussy, Villejuif, France.
Sandra Ortiz-CuaranUniversité de Lyon, Université Claude Bernard Lyon 1, INSERM U1052, CNRS UMR5286, Centre Léon Bérard, Cancer Research Center of Lyon, 69008 Lyon, France.
Karen HowarthInivata, Cambridge, United Kingdom.
David PlanchardCancer Medicine Department, Gustave Roussy, Villejuif, France.
Virginie AvrillonDepartment of Medical Oncology, Centre Léon Bérard Lyon, France.
Gonzalo RecondoINSERM U981, Gustave Roussy, Université Paris Saclay, Villejuif, France.
Solène MarteauDepartment of Medical Oncology, Centre Léon Bérard Lyon, France.
Jose Carlos BenitezCancer Medicine Department, Gustave Roussy, Villejuif, France.
Frank De KievitInivata, Cambridge, United Kingdom.
Vincent PlagnolInivata, Cambridge, United Kingdom.
Ludovic LacroixPlateforme de Génomique, Module de Biopathologie Moléculaire et Centre de Ressources Biologiques, AMMICa, INSERM US23/CNRS UMS3655, Gustave Roussy, Villejuif, France.
Luc OdierDepartment of Pneumology, Hôpital Nord-Ouest Villefranche, Villefranche Sur Saône, France.
Etienne RouleauPlateforme de Génomique, Module de Biopathologie Moléculaire et Centre de Ressources Biologiques, AMMICa, INSERM US23/CNRS UMS3655, Gustave Roussy, Villejuif, France.
Pierre FournelDepartment of Medical Oncology, Institut de Cancérologie de la Loire, Saint-Priest-en-Jarez, France.
Caroline CaramellaRadiology Department, Gustave Roussy, Villejuif, France.
Claire TissotDepartment of Pneumology, CHU Nord Saint-Etienne, Saint-Priest-en-Jarez, France.
Julien AdamPathology Department, Gustave Roussy, Villejuif, France.
Samuel WoodhouseInivata, Cambridge, United Kingdom.
Claudio NicotraEarly Drug Development Department, Gustave Roussy, Villejuif, France.
Edouard AuclinMedical Oncology Department, George Pompidou Hospital, Paris, France.
Jordi RemonHospital HM Delfos, Barcelona, Spain.
Clive MorrisInivata, Cambridge, United Kingdom.
Emma GreenInivata, Cambridge, United Kingdom.
Christophe MassardINSERM U981, Gustave Roussy, Université Paris Saclay, Villejuif, France.
Maurice PérolDepartment of Medical Oncology, Centre Léon Bérard Lyon, France.
Luc FribouletINSERM U981, Gustave Roussy, Université Paris Saclay, Villejuif, France.
Benjamin BesseCancer Medicine Department, Gustave Roussy, Villejuif, France.
Pierre SaintignyDepartment of Medical Oncology, Centre Léon Bérard Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLiquid biopsy specimen genomic profiling is integrated in non-small-cell lung cancer (NSCLC) guidelines; however, data on the clinical relevance for PATIENTS AND

methodsPatients with advanced

resultsOf the 128 patients included in the study, 101 were positive for

conclusionNext-generation, targeted, amplicon-based sequencing for liquid biopsy specimen profiling provides clinically relevant detection of

Identifiers

PMID32923908
PMCPMC7448797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.