Evidence map›Paper›PMID 32923881›Full record

ArticleJCO precision oncology2020

Severe Capecitabine Toxicity Associated With a Rare

Reynold C Ly, Remington E Schmidt, Patrick J Kiel, Victoria M Pratt, Bryan P Schneider, Milan Radovich, Steven M Offer, Robert B Diasio, Todd C Skaar

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in JCO precision oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Identification of a largeFrontiers in pharmacology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Clinical Implementation of Rare and NovelInternational journal of biological sciences · 2024
    Review
  11. Rare genetic variant burden in DPYD predicts severe fluoropyrimidine-related toxicity risk.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Reynold C LyDepartment of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN.
Remington E SchmidtDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN.
Patrick J KielDepartment of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN.
Victoria M PrattDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN.
Bryan P SchneiderDivision of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN.
Milan RadovichDivision of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN.
Steven M OfferDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN.
Robert B DiasioDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN.
Todd C SkaarDepartment of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN.
Indiana University – Purdue University Indianapolis · USMayo Clinic · USIndiana University School of Medicine

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
MIRA-Regulation of drug metabolizing enzymesR35GM131812 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI SKAAR, TODD C. · 2019 to 2023
$2.5M
NCI NIH HHS P30 CA015083NIGMS NIH HHS R35 GM131812
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID32923881
PMCPMC7446391
OpenAlexW3034991941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.