Evidence map›Paper›PMID 32923844›Full record

ArticleAPL bioengineering2020

Combined gas embolization and chemotherapy can result in complete tumor regression in a murine hepatocellular carcinoma model.

Jennifer N Harmon, Foad Kabinejadian, Joseph L Bull

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jennifer N HarmonDepartment of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA.ORCID 0000-0002-9013-519X
Foad KabinejadianDepartment of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA.
Joseph L BullDepartment of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA.ORCID 0000-0003-4706-3167
Tulane University · US

Funding

Dynamics of Vascular Microbubbles and Microdroplets in Gas EmbolotherapyR01EB006476 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BULL, JOSEPH L · 2007 to 2016
$4.1M
NIBIB NIH HHS R01 EB006476
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is an intractable cancer with a high mortality rate. Transarterial chemoembolization (TACE), a non-curative method, is the first line therapy for intermediate stage patients. This effectively extends patient survival but requires a complicated intraarterial catheterization procedure and is poorly suited to repeated administration. Here, we investigate gas chemoembolization, a less invasive, more easily administered transient occlusion method that circumvents these limitations. We examined the efficacy of repeated embolization combined with systemically administered doxorubicin, the most common chemotherapeutic in TACE, or tirapazamine, a hypoxia-activated cytotoxic agent, in an ectopic xenograft model of HCC. Emboli were generated

Identifiers

PMID32923844
PMCPMC7481009
OpenAlexW3084214099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.