ArticleScience advances2020
Unmasking selective path integration deficits in Alzheimer's disease risk carriers.
Registry-linked trialAbstract read
In one paragraph
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05155397 (The Dortmund Vital Study), which is not on this map. Cited by 64 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability Across the Lifespan. An Interdisciplinary, Cross-sectional and Longitudinal Study
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Virtual Reality and Serious Videogame-Based Instruments for Assessing Spatial Navigation in Alzheimer's Disease: A Systematic Review of Psychometric Properties.Neuropsychology review · 2025Pooled it
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Article
- Article
- Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.Annual review of neuroscience · 2026Review
- Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.Cell reports · 2026Article
- Spatial navigation as a digital marker for clinically differentiating cognitive impairment severity.Communications medicine · 2026Article
- Cortisol treatment impairs path integration and alters grid-like representations in the male human entorhinal cortex.PLoS biology · 2026Article
- Egocentric Spatial Memory Deficit in Amnestic Mild Cognitive Impairment Revealed Through Virtual Reality: Cross-Sectional Study.JMIR aging · 2026Article
- The Contribution of Spatially Tuned Brain Cells to Human Navigation Performance.KN - journal of cartography and geographic information · 2026Review
- Distinctive roles of left and right entorhinal cortex in path integration via a non-invasive stimulation study.Nature communications · 2025Article
- Theta Activity Supports Landmark-Based Correction of Naturalistic Human Path Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Investigating the associations between tau and mental orientation among cognitively unimpaired individuals.Journal of Alzheimer's disease : JAD · 2025Article
- Grid cells accurately track movement during path integration-based navigation despite switching reference frames.Nature neuroscience · 2025Article
- Path integration impairments reveal early cognitive changes in subjective cognitive decline.Science advances · 2025Article
- Path integration impairments reveal early cognitive changes in Subjective Cognitive Decline.bioRxiv : the preprint server for biology · 2025Article
- p16-expressing microglia and endothelial cells promote tauopathy and neurovascular abnormalities in PS19 mice.Neuron · 2025Article
- Spatial periodicity in grid cell firing is explained by a neural sequence code of 2-D trajectories.eLife · 2025Article
- A cognitive-motor framework for spatial navigation in aging and early-stage Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Review
- Rotation errors in path integration are associated with Alzheimer's disease tau pathology: a cross-sectional study.Alzheimer's research & therapy · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Anne BierbrauerDepartment of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.ORCID 0000-0002-3803-7015
Lukas KunzEpilepsy Center, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106 Freiburg im Breisgau, Germany.ORCID 0000-0002-0665-7703
Carlos A GomesDepartment of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.
Maike LuhmannFaculty of Psychology, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0001-6211-9304
Lorena DeukerDepartment of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.
Stephan GetzmannLeibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany.
Edmund WascherLeibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany.
Patrick D GajewskiLeibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany.
Jan G HengstlerLeibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany.
Marina Fernandez-AlvarezLaboratory of Functional Neuroscience, Pablo de Olavide University, Network Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Seville, Spain.ORCID 0000-0002-9258-3439
Mercedes AtienzaLaboratory of Functional Neuroscience, Pablo de Olavide University, Network Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Seville, Spain.
Davide M CammisuliDepartment of Medicine and Surgery, Laboratory of Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology, University of Parma, Parma, Italy.
Francesco BonattiDepartment of Medicine and Surgery, Medical Genetics, University of Parma, Parma, Italy.
Carlo PrunetiDepartment of Medicine and Surgery, Laboratory of Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology, University of Parma, Parma, Italy.ORCID 0000-0002-7686-0766
Antonio PercesepeDepartment of Medicine and Surgery, Medical Genetics, University of Parma, Parma, Italy.ORCID 0000-0002-3268-6786
Youssef BellaaliDepartment of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.
Bernard HanseeuwDepartment of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.
Bryan A StrangeDepartment of Neuroimaging, Alzheimer's Disease Research Centre, Reina Sofia-CIEN Foundation, Madrid, Spain.ORCID 0000-0001-6476-4091
Jose L CanteroLaboratory of Functional Neuroscience, Pablo de Olavide University, Network Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Seville, Spain.
Nikolai AxmacherDepartment of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.ORCID 0000-0002-0475-6492
Funding
Using Direct Brain Stimulation to Study Cognitive ElectrophysiologyU01NS113198 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KAHANA, MICHAEL JACOB · 2019 to 2023
$6.9MNINDS NIH HHS U01 NS113198
Abstract
Alzheimer's disease (AD) manifests with progressive memory loss and spatial disorientation. Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of young adults at genetic risk for AD (
Indexed as
Alzheimer DiseaseApolipoprotein E4Entorhinal CortexHeterozygoteHumansMagnetic Resonance ImagingYoung AdultApolipoprotein E4
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT05155397ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.