ArticleScience advances2020
Ingestible transiently anchoring electronics for microstimulation and conductive signaling.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 67 citations in OpenAlex.
- A frequency-dependent phase-transition bioelectronic device with in-situ signal-filtering and Janus-adhesive capabilities for low-artifact sensing and tendon repair.Materials today. Bio · 2026Article
- Toward autonomous robotic-assisted and microrobotic surgery.Science advances · 2026Review
- Transforming healthcare through in-body bioelectronic systems.Nature communications · 2026Review
- Gut-brain axis in health and brain disease.Chinese medical journal · 2026Review
- The Gastrointestinal Tract: A Unique Battlefield for Bioengineering Delivery Platforms.Bioengineering (Basel, Switzerland) · 2025Review
- Enteric nervous system as a therapeutic target in gastrointestinal disorders.World journal of gastrointestinal pharmacology and therapeutics · 2025Article
- A Low-Friction Capsule Robot with Drive-Control-Sensing Integration for Gastrointestinal Lesion Detection.Research (Washington, D.C.) · 2025Article
- Capsule robots for the monitoring, diagnosis, and treatment of intestinal diseases.Materials today. Bio · 2024Review
- Design and fabrication of a parasite-inspired, millimeter-scale tissue anchoring mechanism.PNAS nexus · 2024Article
- An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut.Nature communications · 2024Article
- Robotic wireless capsule endoscopy: recent advances and upcoming technologies.Nature communications · 2024Review
- Review article: Current status and future directions of ingestible electronic devices in gastroenterology.Alimentary pharmacology & therapeutics · 2024Review
- Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation.Science robotics · 2023Article
- Gelatin-Based Ingestible Impedance Sensor to Evaluate Gastrointestinal Epithelial Barriers.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Wirelessly powered deformable electronic stent for noninvasive electrical stimulation of lower esophageal sphincter.Science advances · 2023Article
- Ingestible Functional Magnetic Robot with Localized Flexibility (MR-LF).Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2022Article
- Gut markers of bodily self-consciousness in men.iScience · 2022Article
- State of the Art in Smart Portable, Wearable, Ingestible and Implantable Devices for Health Status Monitoring and Disease Management.Sensors (Basel, Switzerland) · 2022Review
- Foundations of gastrointestinal-based drug delivery and future developments.Nature reviews. Gastroenterology & hepatology · 2022Review
- Mucosa-interfacing electronics.Nature reviews. Materials · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
Abstract
Ingestible electronic devices enable noninvasive evaluation and diagnosis of pathologies in the gastrointestinal (GI) tract but generally cannot therapeutically interact with the tissue wall. Here, we report the development of an orally administered electrical stimulation device characterized in ex vivo human tissue and in in vivo swine models, which transiently anchored itself to the stomach by autonomously inserting electrically conductive, hooked probes. The probes provided stimulation to the tissue via timed electrical pulses that could be used as a treatment for gastric motility disorders. To demonstrate interaction with stomach muscle tissue, we used the electrical stimulation to induce acute muscular contractions. Pulses conductively signaled the probes' successful anchoring and detachment events to a parenterally placed device. The ability to anchor into and electrically interact with targeted GI tissues controlled by the enteric nervous system introduces opportunities to treat a multitude of associated pathologies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.