ArticleStructural dynamics (Melville, N.Y.)2020
Role of intracellular water in the normal-to-cancer transition in human cells-insights from quasi-elastic neutron scattering.
Article in Structural dynamics (Melville, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- A novel model based on apparent diffusion coefficient and signal intensity on MRI to quantify subtle internal difference between tumor-adjacent and -distant liver tissues in TBMC medical imaging · 2026Article
- Identifying phenotypes of colorectal malignant tumors using the quasi-bound state in the continuum of a terahertz metasurface biosensor.Biomedical optics express · 2025Article
- Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue.Oncology letters · 2025Article
- Deuterium magnetic resonance imaging of tumors using low-dose systemic deuterated water labeling.Frontiers in oncology · 2025Article
- Markers of low field NMR relaxation features of tissues.Scientific reports · 2024Article
- Long-lasting, biochemically modified mRNA, and its frameshifted recombinant spike proteins in human tissues and circulation after COVID-19 vaccination.Pharmacology research & perspectives · 2024Review
- Mitochondrial-Stem Cell Connection: Providing Additional Explanations for Understanding Cancer.Metabolites · 2024Article
- Dynamic Changes in Body Composition and Protein Intake in Epithelial Ovarian Cancer Patients Undergoing Chemotherapy: A Preliminary Study.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- The biophysics of water in cell biology: perspectives on a keystone for both marine sciences and cancer research.Frontiers in cell and developmental biology · 2024Article
- High-content stimulated Raman histology of human breast cancer.Theranostics · 2024Article
- Cellular dynamics as a marker of normal-to-cancer transition in human cells.Scientific reports · 2023Article
- Nanocomposite Hydrogels and Extracellular Matrix-Advantages and Associated Risks.Gels (Basel, Switzerland) · 2023Review
- Exploring the Limits of Biological Complexity Amenable to Studies by Incoherent Neutron Spectroscopy.Life (Basel, Switzerland) · 2022Review
- Water Dynamics in Cancer Cells: Lessons from Quasielastic Neutron Scattering.Medicina (Kaunas, Lithuania) · 2022Review
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6 authors.
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Abstract
The transition from normal to malignant state in human cells is still a poorly understood process. Changes in the dynamical activity of intracellular water between healthy and cancerous human cells were probed as an innovative approach for unveiling particular features of malignancy and identifying specific reporters of cancer. Androgen-unresponsive prostate and triple-negative breast carcinomas were studied as well as osteosarcoma, using the technique of quasi-elastic neutron scattering. The cancerous cells showed a considerably higher plasticity relative to their healthy counterparts, this being more significant for the mammary adenocarcinoma. Also, the data evidence that the prostate cancer cells display the highest plasticity when compared to triple-negative mammary cancer and osteosarcoma, the latter being remarkably less flexible. Furthermore, the results suggest differences between the flexibility of different types of intracellular water molecules in normal and cancerous cells, as well as the number of molecules involved in the different modes of motion. The dynamics of hydration water molecules remain virtually unaffected when going from healthy to cancer cells, while cytoplasmic water (particularly the rotational motions) undergoes significant changes upon normal-to-cancer transition. The results obtained along this study can potentially help to understand the variations in cellular dynamics underlying carcinogenesis and tumor metastasis, with an emphasis on intracellular water.
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