Evidence map›Paper›PMID 32923442›Full record

ArticleFrontiers in cell and developmental biology2020

Leukemia Inhibitory Factor (LIF) Overexpression Increases the Angiogenic Potential of Bone Marrow Mesenchymal Stem/Stromal Cells.

Girlaine Café Santos, Daniela Nascimento Silva, Vitor Fortuna, Brysa Mariana Silveira, Iasmim Diniz Orge, Thaís Alves de Santana, Gabriela Louise Sampaio, Bruno Diaz Paredes, Ricardo Ribeiro-Dos-Santos, Milena Botelho Pereira Soares

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Girlaine Café SantosGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.
Daniela Nascimento SilvaGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.
Vitor FortunaHealth Sciences Institute, Federal University of Bahia, Salvador, Brazil.
Brysa Mariana SilveiraHealth Sciences Institute, Federal University of Bahia, Salvador, Brazil.
Iasmim Diniz OrgeGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.
Thaís Alves de SantanaGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.
Gabriela Louise SampaioGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.
Bruno Diaz ParedesResearch D'Or Institute, Rio de Janeiro, Brazil.
Ricardo Ribeiro-Dos-SantosGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.
Milena Botelho Pereira SoaresGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.
Fundação Oswaldo Cruz · BRServiço Nacional de Aprendizagem Industrial · BRUniversidade Federal da Bahia · BRD’Or Institute for Research and Education · BRNational Institute of Science and Technology in Regenerative Medicine · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem/stromal cells (MSCs) have the ability to secrete bioactive molecules, exerting multiple biological effects, such as tissue regeneration, reduction of inflammation, and neovascularization. The therapeutic potential of MSCs can be increased by genetic modification to overexpress cytokines and growth factors. Here we produced mouse MSCs overexpressing human leukemia inhibitory factor (LIF) to assess their proangiogenic potential

Indexed as

angiogenesisgenetic modificationLIFmesenchymal stem/stromal cellsproangiogenico factors

Identifiers

PMID32923442
PMCPMC7456813
OpenAlexW3049270212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.