ArticleJournal of oral biology and craniofacial research
Validity of Toluidine Blue test as a diagnostic tool for high risk oral potentially malignant disorders- a multicentre study in Sri Lanka.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Salivary metabolomics in oral potentially malignant disorders and oral cancer patients-a systematic review with meta-analysis.Clinical oral investigations · 2024Pooled it
- In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders-Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.The Cochrane database of systematic reviews · 2021Pooled it
- The Diagnostic Potential of Non-Invasive Tools for Oral Cancer and Precancer: A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Effectiveness of adjunctive screening tools for potentially malignant oral disorders and oral cancer: A systematic review.The Saudi dental journal · 2024Review
- Accuracy of special histochemical staining methods in diagnosis of oral pathology: A systematic review and meta-analysis.Dental research journal · 2024Review
- Are the imaging-based techniques for early diagnosis of oral potentially malignant lesions effective?Evidence-based dentistry · 2022Article
- Comparison of CEA and IgG serum levels in oral lichenoid lesions before and after treatment with topical corticosteroids.Journal of dental research, dental clinics, dental prospects · 2022Article
- Knowledge of Oral Cancer among Online Respondent General Dentists: A Cross-sectional Survey.JNMA; journal of the Nepal Medical Association · 2021Article
- Toluidine Blue Test for Early Detection of High-risk Oral Potentially Malignant Disorders and Oral Cancer - An Evaluative Study.Annals of maxillofacial surgeryArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction- Early detection plays a major role to reduce the mortality of oral squamous cell carcinoma (OSCC). Many adjunctive techniques have emerged with claims of differentiating high risk oral potentially malignant disorders (OPMDs) from benign lesions. Toluidine blue (TB) test has been established as a diagnostic adjunct in detecting high risk OPMDs and early asymptomatic OSCCs. As majority of OSCC are preceded by OPMDs, recognition of them at an early stage is important in the management of this devastating disease.
methods-This study was conducted as a multi-center study prospectively for a period of 2 years. Sixty five patients presented with OPMDs were selected and TB test was performed followed by a biopsy for histopathological confirmation. Criterion validity was assessed with histological diagnosis of the incisional biopsy of the OPMD as a gold standard test verses TB test results.
resultsThe sensitivity of the TB test was 68.3% and the specificity 63.1% with a false positive rate of 36.8% and false negative rate of 31.7%. However, the predictive value of the positive test was 80%.
conclusion- TB testing might be a potential adjunct diagnostic aid in identifying high risk OPMDs. Further studies with extensive sample size and different demographics are needed to validate our findings.
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