Evidence map›Paper›PMID 32923314›Full record

ReviewNanotheranostics2020

Local delivery of insulin/IGF-1 for bone regeneration: carriers, strategies, and effects.

Xiaoxuan Zhang, Helin Xing, Feng Qi, Hongchen Liu, Lizeng Gao, Xing Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nanotheranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Trial
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  6. Contribution of insulin‑like growth factor‑1 to tendon repair (Review).International journal of molecular medicine · 2025
    Review
  7. Article
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  14. Bone Loss in Diabetes Mellitus: Diaporosis.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoxuan ZhangShanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, China.
Helin XingDepartment of Prosthodontics, Beijing Stomatological Hospital and School of Stomatology, Capital Medical University, Beijing, 100050, China.
Feng QiDepartment of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO, USA.
Hongchen LiuInstitute of Stomatology & Oral Maxilla Facial Key Laboratory, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Lizeng GaoCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Xing WangShanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects caused by trauma, tumor resection, congenital malformation and infection are still a major challenge for clinicians. Biomimetic bone materials have attracted more and more attention in science and industry. Insulin and insulin-like growth factor-1 (IGF-1) have been increasingly recognized as an inducible factor for osteogenesis and angiogenesis. Spatiotemporal release of insulin may serve as the promising strategy. Considering the successful application of nanoparticles in drug loading, various insulin delivery systems have been developed, including (poly (lactic-co-glycolic acid), PLGA), hydroxyapatite (HA), gelatin, chitosan, alginate, and (γ-glutamic acid)/β-tricalcium phosphate, γ-PGA/β-TCP). Here, we have reviewed the progress on nanoparticles carrying insulin/IGF for bone regeneration. In addition, the key regulatory mechanism of insulin in bone regeneration is also summarized. The future application strategies and the challenges in bone regeneration are also discussed.

Indexed as

Bone RegenerationInsulinInsulin-Like Growth Factor INanoparticlesAnimalsDrug Delivery SystemsHumansMiceRatsInsulinInsulin-Like Growth Factor IAngiogenesisBone regenerationInsulinInsulin-like growth factorNanoparticlesOsteogenesis

Identifiers

PMID32923314
PMCPMC7484631

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.