Evidence map›Paper›PMID 32923170›Full record

ArticleOncoimmunology2020

IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice.

Leland G Richardson, Linda T Nieman, Anat O Stemmer-Rachamimov, Xijin S Zheng, Khalifa Stafford, Hiroaki Nagashima, Julie J Miller, Juri Kiyokawa, David T Ting, Hiroaki Wakimoto and 3 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Mutant IDH Modulates Suppressive Myeloid Populations in Malignant Glioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Cancer vaccine strategies for the treatment of diffusely infiltrating gliomas.Therapeutic advances in vaccines and immunotherapy · 2023
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Leland G RichardsonTranslational Brain Tumor Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Linda T NiemanCancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Anat O Stemmer-RachamimovDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Xijin S ZhengTranslational Brain Tumor Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Khalifa StaffordTranslational Brain Tumor Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hiroaki NagashimaDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Julie J MillerDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Juri KiyokawaDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
David T TingCancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hiroaki WakimotoDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Daniel P CahillDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Bryan D ChoiTranslational Brain Tumor Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
William T CurryTranslational Brain Tumor Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Harvard University · USMassachusetts General Hospital · US

Funding

Targeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WENDY Beth LONDON · 2013 to 2026
$33.5M
Neuroscience Resident Research ProgramR25NS065743 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, WILLIAMS, ZIV · 2009 to 2023
$11.8M
NCI NIH HHS P50 CA165962NINDS NIH HHS R25 NS065743
6 · The paper itself

Abstract

The metabolic gene isocitrate dehydrogenase 1 (

Indexed as

Brain NeoplasmsGliomaAnimalsHumansIsocitrate DehydrogenaseMiceMutationT-Lymphocytes, RegulatoryIsocitrate DehydrogenaseGliomaIDH-mutationimmune microenvironmentRegulatory T cells

Identifiers

PMID32923170
PMCPMC7458656
OpenAlexW3081135066

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.