ArticleAmerican journal of blood research2020
TAB3 overexpression promotes NF-κB activation and inflammation in acute pancreatitis.
Article in American journal of blood research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Hsa-microRNA-27b-3p inhibits hepatocellular carcinoma progression by inactivating transforming growth factor-activated kinase-binding protein 3/nuclear factor kappa B signalling.Cellular & molecular biology letters · 2022Article
- LncRNA UCA1 Accelerates the Progression of Ulcerative Colitis via Mediating the miR-331-3p/BRD4 Axis.International journal of general medicine · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute pancreatitis (AP) is a clinically common inflammatory disease, NF-κB activation and the secretion of pro-inflammatory mediators have been considered as the main events of AP. According to reports, TAB3 is essential for NF-κB activation and participates in inflammatory responses. In this study, we used caerulein to establish an AP rat model and cell model. The expression of TAB3 was measured both in control group and AP group by Western blot and Immunohistochemistry. We firstly found the expression of TAB3 was significantly increased in caerulein-induced AP rat and cell model compared with control group, especially at 8 h. Furthermore, the increasing expression of TAB3 in AP group was also accompanied by increased levels of pro-inflammatory mediators (TNF-α, IL-6 and LDH). In addition, the decreasing expression of TAB3 in TAB3-siRNA transfected AP AR42J cells was accompanied by reduced levels of pro-inflammatory cytokines and inhibited the production of p-P65. These findings suggested that TAB3 may accelerate the inflammatory responses of AP through NF-κB activation.
Indexed as
Identifiers
32923091PMC7486491W3084812569What OpenQuestion holds
Registered trials
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