ArticleBiomedical optics express2020
Hematocrit significantly confounds diffuse correlation spectroscopy measurements of blood flow.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Correlation between diffuse correlation spectroscopy and transcranial Doppler ultrasound in pediatric sickle cell disease.Biomedical optics express · 2026Article
- Non-invasive monitoring of microcirculation dynamics in hypovolemic shock: a novel application of diffuse correlation spectroscopy.Intensive care medicine experimental · 2025Article
- Hybrid diffuse optical appraisal of peripheral and cerebral changes in critically ill patients receiving red blood cell transfusion.Biophotonics discovery · 2025Article
- Effects of red blood cell transfusion on cerebral hemodynamics of preterm neonates.Neurophotonics · 2024Article
- Modified Beer-Lambert algorithm to measure pulsatile blood flow, critical closing pressure, and intracranial hypertension.Biomedical optics express · 2024Article
- DCS blood flow index underestimates skeletal muscle perfusionJournal of biomedical optics · 2024Article
- Comparison of diffuse correlation spectroscopy analytical models for measuring cerebral blood flow in adults.Journal of biomedical optics · 2023Article
- Article
- Deep-learning-based separation of shallow and deep layer blood flow rates in diffuse correlation spectroscopy.Biomedical optics express · 2023Article
- Normative cerebral microvascular blood flow waveform morphology assessed with diffuse correlation spectroscopy.Biomedical optics express · 2023Article
- Diffuse correlation spectroscopy: current status and future outlook.Neurophotonics · 2023Article
- Quantifying the Cerebral Hemometabolic Response to Blood Transfusion in Pediatric Sickle Cell Disease With Diffuse Optical Spectroscopies.Frontiers in neurology · 2022Article
- Time-domain diffuse correlation spectroscopy (TD-DCS) for noninvasive, depth-dependent blood flow quantification in human tissue in vivo.Scientific reports · 2021Article
- Improved accuracy of cerebral blood flow quantification in the presence of systemic physiology cross-talk using multi-layer Monte Carlo modeling.Neurophotonics · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Diffuse correlation spectroscopy (DCS) is an optical modality used to measure an index of blood flow in biological tissue. This blood flow index depends on both the red blood cell flow rate and density (i.e., hematocrit), although the functional form of hematocrit dependence is not well delineated. Herein, we develop and validate a novel tissue-simulating phantom containing hundreds of microchannels to investigate the influence of hematocrit on blood flow index. For a fixed flow rate, we demonstrate a significant inverse relationship between hematocrit and blood flow index that must be accounted for to accurately estimate blood flow under anemic conditions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.