ArticleBiomedical optics express2020
Visualizing human photoreceptor and retinal pigment epithelium cell mosaics in a single volume scan over an extended field of view with adaptive optics optical coherence tomography.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Characterization of retinal pigment epithelium layer in healthy and diseased retinas with high-resolution adaptive optics transscleral flood illumination imaging.Acta ophthalmologica · 2026Article
- Age-Related Associations of Foveal Structural Parameters in Healthy Adults: A Comparative Analysis of Biological and Chronological Age.Vision (Basel, Switzerland) · 2026Article
- Enhancing volumetric microscopy with blind computational correction of spatially variant aberrations using neural field representation.bioRxiv : the preprint server for biology · 2026Article
- A Study of Why We Need to Reassess Full Reference Image Quality Assessment with Medical Images.Journal of imaging informatics in medicine · 2025Review
- Image Quality in Adaptive Optics Optical Coherence Tomography of Diabetic Patients.Diagnostics (Basel, Switzerland) · 2025Article
- On the improvement of schizophrenia detection with optical coherence tomography data using deep neural networks and aggregation functions.Scientific reports · 2024Article
- Identifying retinal pigment epithelium cells in adaptive optics-optical coherence tomography images with partial annotations and superhuman accuracy.Biomedical optics express · 2024Article
- Improvements on speed, stability and field of view in adaptive optics OCT for anterior retinal imaging using a pyramid wavefront sensor.Biomedical optics express · 2024Article
- Comparison between Two Adaptive Optics Methods for Imaging of Individual Retinal Pigmented Epithelial Cells.Diagnostics (Basel, Switzerland) · 2024Article
- Age-Related Macular Degeneration, a Mathematically Tractable Disease.Investigative ophthalmology & visual science · 2024Review
- Volumetric Reconstruction of a Human Retinal Pigment Epithelial Cell Reveals Specialized Membranes and Polarized Distribution of Organelles.Investigative ophthalmology & visual science · 2023Article
- Twenty-five years of clinical applications using adaptive optics ophthalmoscopy [Invited].Biomedical optics express · 2023Review
- Advances in Optical Coherence Tomography Imaging Technology and Techniques for Choroidal and Retinal Disorders.Journal of clinical medicine · 2022Review
- Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking.Scientific reports · 2022Article
- Histology and clinical imaging lifecycle of black pigment in fibrosis secondary to neovascular age-related macular degeneration.Experimental eye research · 2022Article
- Analysis of mitochondrial dynamics and function in the retinal pigment epithelium by high-speed high-resolution live imaging.Frontiers in cell and developmental biology · 2022Article
- Retinal adaptive optics imaging with a pyramid wavefront sensor.Biomedical optics express · 2021Article
- Reflective mirror-based line-scan adaptive optics OCT for imaging retinal structure and function.Biomedical optics express · 2021Article
- Human Foveal Cone and Müller Cells Examined by Adaptive Optics Optical Coherence Tomography.Translational vision science & technology · 2021Article
- Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium.Investigative ophthalmology & visual science · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using adaptive optics optical coherence tomography, human photoreceptors and retinal pigment epithelium (RPE) cells are typically visualized on a small field of view of ∼1° to 2°. In addition, volume averaging is required for visualizing the RPE cell mosaic. To increase the imaging area, we introduce a lens based spectral domain AO-OCT system that shows low aberrations within an extended imaging area of 4°×4° while maintaining a high (theoretical) transverse resolution (at >7 mm pupil diameter) in the order of 2 µm. A new concept for wavefront sensing is introduced that uses light mainly originating from the RPE layer and yields images of the RPE cell mosaic in a single volume acquisition. The capability of the instrument for in vivo imaging is demonstrated by visualizing various cell structures within the posterior retinal layers over an extended field of view.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.