ArticleBiomedical optics express2020
Evaluating β-amyloidosis progression in Alzheimer's disease with Mueller polarimetry.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Novel histological observation method using the scattered light of unstained collagen sections.Scientific reports · 2026Article
- Polarimetric analysis of the Alzheimer's pathology in excised mouse brain tissue.Journal of biomedical optics · 2026Article
- Retardance and depolarization of brain white matter as markers for intraoperative delineation of brain tumors: experiments and simulations.Biomedical optics express · 2025Article
- Discerning Amyloid‑β and Tau Pathologies with Learning-Based Quantum Sensing.ACS photonics · 2025Article
- Quantitative diagnosis of amyloid without Congo red staining using polarized light microscopy.Biomedical optics express · 2025Article
- PoLambRimetry: a multispectral polarimetric atlas of lamb brain.Journal of biomedical optics · 2024Article
- Stereoscopic spatial graphical method of Mueller matrix: Global-Polarization Stokes Ellipsoid.Frontiers of optoelectronics · 2024Article
- Exploring the evolution of circular polarized light backscattered from turbid tissue-like disperse medium utilizing generalized Monte Carlo modeling approach with a combined use of Jones and Stokes-Mueller formalisms.Journal of biomedical optics · 2024Article
- Analyzing the influence of oblique incidence on quantitative backscattering tissue polarimetry: a pilotJournal of biomedical optics · 2023Article
- Detection and analysis of chiral molecules as disease biomarkers.Nature reviews. Chemistry · 2023Review
- Robustness of the wide-field imaging Mueller polarimetry for brain tissue differentiation and white matter fiber tract identification in a surgery-like environment: anBiomedical optics express · 2023Article
- Effects of formalin fixation on polarimetric properties of brain tissue: fresh or fixed?Neurophotonics · 2023Article
- A Dual-Modality Imaging Method Based on Polarimetry and Second Harmonic Generation for Characterization and Evaluation of Skin Tissue Structures.International journal of molecular sciences · 2023Article
- Decoherence of photon entanglement by transmission through brain tissue with Alzheimer's disease.Biomedical optics express · 2022Article
- Automatic pseudo-coloring approaches to improve visual perception and contrast in polarimetric images of biological tissues.Scientific reports · 2022Article
- Toward the development of a polarimetric tool to diagnose the fibrotic human ventricular myocardium.Journal of biomedical optics · 2022Article
- Polarimetric visualization of healthy brain fiber tracts under adverse conditions:Biomedical optics express · 2021Article
- Influence of the anatomical features of different brain regions on the spatial localization of fiber photometry signals.Biomedical optics express · 2021Article
- Polarimetric data-based model for tissue recognition.Biomedical optics express · 2021Article
- Stokes polarization imaging applied for monitoring dynamic tissue optical clearing.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We applied the wide-field Mueller imaging polarimetry for the screening of formalin-fixed paraffin-embedded samples of mouse brain tissue at different stages of brain β-amyloidosis in Alzheimer's disease (AD). The accumulation of amyloid-beta (Aβ) deposits throughout the brain tissue is one of the key pathological hallmarks observed with the AD progression. We demonstrate that the presence of Aβ plaques influences the properties of backscattered polarized light, in particular, its degree of depolarization. By means of statistical analysis, we demonstrate that the high-order statistical moments of depolarization distributions, acquired with the multi-spectral Mueller imaging polarimetry, can be used as sensitive markers of the growing presence of Aβ plaques. The introduced label-free polarimetric approach has a potential to facilitate the current practice of the histopathology screening in terms of diagnosis accuracy, time and cost efficiency.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.